======= NRARP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRARP
  * **<color #00a2e8>Official Name</color>**: NOTCH regulated ankyrin repeat protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=441478|441478]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6K4|Q7Z6K4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRARP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRARP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619987|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity). {ECO:0000250|UniProtKB:Q91ZA8, ECO:0000269|PubMed:19154719, ECO:0000269|PubMed:25985737, ECO:0000305|PubMed:25985737}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Notch signaling pathway involved in somitogenesis|
|regulation of Notch signaling pathway involved in somitogenesis|
|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|regulation of somitogenesis|
|somite rostral/caudal axis specification|
|endothelial cell proliferation|
|negative regulation of embryonic development|
|branching involved in blood vessel morphogenesis|
|embryonic axis specification|
|negative regulation of Notch signaling pathway|
|negative regulation of T cell differentiation|
|anterior/posterior axis specification|
|negative regulation of lymphocyte differentiation|
|sprouting angiogenesis|
|embryonic pattern specification|
|somitogenesis|
|somite development|
|axis specification|
|epithelial cell proliferation|
|positive regulation of endothelial cell proliferation|
|segmentation|
|negative regulation of leukocyte differentiation|
|regulation of Notch signaling pathway|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|Notch signaling pathway|
|regulation of endothelial cell proliferation|
|regulation of embryonic development|
|branching morphogenesis of an epithelial tube|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of lymphocyte activation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|positive regulation of Wnt signaling pathway|
|positive regulation of epithelial cell proliferation|
|negative regulation of cell activation|
|anterior/posterior pattern specification|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|epithelial tube morphogenesis|
|regulation of T cell activation|
|angiogenesis|
|regionalization|
|regulation of epithelial cell proliferation|
|regulation of Wnt signaling pathway|
|regulation of cell-cell adhesion|
|blood vessel morphogenesis|
|morphogenesis of an epithelium|
|pattern specification process|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|blood vessel development|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|cell population proliferation|
|tissue morphogenesis|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|embryo development|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|negative regulation of gene expression|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17105
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRARP Expression in NALM6 Cells: -0.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>