======= NSD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSD1
  * **<color #00a2e8>Official Name</color>**: nuclear receptor binding SET domain protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64324|64324]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96L73|Q96L73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606681|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|PWWP|
|SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone methyltransferase activity (H4-K20 specific)|
|regulation of histone H3-K36 methylation|
|histone H3-K36 methylation|
|histone methyltransferase activity (H3-K36 specific)|
|histone H4-K20 methylation|
|retinoic acid receptor binding|
|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|retinoid X receptor binding|
|thyroid hormone receptor binding|
|estrogen receptor binding|
|androgen receptor binding|
|regulation of transcription regulatory region DNA binding|
|regulation of histone methylation|
|histone lysine methylation|
|transcription coregulator activity|
|peptidyl-lysine methylation|
|histone methylation|
|chromatin|
|regulation of DNA binding|
|protein alkylation|
|protein methylation|
|regulation of peptidyl-serine phosphorylation|
|regulation of histone modification|
|regulation of chromatin organization|
|transcription corepressor activity|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|regulation of chromosome organization|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|chromatin binding|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|chromatin organization|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-2.89|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.12|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-2.1|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.85|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.84|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.83|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.83|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.81|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.7|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.71|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.72|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.73|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.74|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.84|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.85|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.86|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.91|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.96|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.96|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.09|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.14|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.22|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.23|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.24|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.24|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.34|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.34|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.39|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.41|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.62|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.79|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.8|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.85|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.85|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.86|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.88|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.9|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.96|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.97|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.11|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|3.18|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|3.53|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|4.64|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|5.07|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|5.67|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|5.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:id3|ID3]]|0.756|
|[[:human genes:b:bap1|BAP1]]|0.735|
|[[:human genes:d:dohh|DOHH]]|0.687|
|[[:human genes:t:trim28|TRIM28]]|0.642|
|[[:human genes:r:rptor|RPTOR]]|0.619|
|[[:human genes:c:cbfb|CBFB]]|0.617|
|[[:human genes:a:asxl2|ASXL2]]|0.603|
|[[:human genes:m:mlst8|MLST8]]|0.573|
|[[:human genes:m:mtor|MTOR]]|0.568|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.552|
|[[:human genes:b:brpf1|BRPF1]]|0.548|
|[[:human genes:s:ssbp2|SSBP2]]|0.533|
|[[:human genes:r:runx1|RUNX1]]|0.532|
|[[:human genes:z:zfx|ZFX]]|0.529|
|[[:human genes:t:thg1l|THG1L]]|0.527|
|[[:human genes:r:rnmt|RNMT]]|0.518|
|[[:human genes:t:tle4|TLE4]]|0.514|
|[[:human genes:v:vhl|VHL]]|0.51|
|[[:human genes:b:bak1|BAK1]]|0.508|
|[[:human genes:w:wdr24|WDR24]]|0.506|
|[[:human genes:p:plaa|PLAA]]|0.499|
|[[:human genes:f:faf2|FAF2]]|0.498|
|[[:human genes:c:casp9|CASP9]]|0.498|
|[[:human genes:g:gfpt1|GFPT1]]|0.498|
|[[:human genes:t:triap1|TRIAP1]]|0.497|
|[[:human genes:l:lmo2|LMO2]]|0.494|
|[[:human genes:x:xpo6|XPO6]]|0.491|
|[[:human genes:u:uap1|UAP1]]|0.49|
|[[:human genes:m:metap2|METAP2]]|0.49|
|[[:human genes:u:ube2g2|UBE2G2]]|0.49|
|[[:human genes:c:ccdc101|CCDC101]]|0.49|
|[[:human genes:c:csnk2b|CSNK2B]]|0.489|
|[[:human genes:b:bptf|BPTF]]|0.487|
|[[:human genes:z:znf592|ZNF592]]|0.483|
|[[:human genes:t:trmt10a|TRMT10A]]|0.476|
|[[:human genes:r:romo1|ROMO1]]|0.475|
|[[:human genes:l:ldb1|LDB1]]|0.472|
|[[:human genes:m:maml1|MAML1]]|0.471|
|[[:human genes:s:scaf8|SCAF8]]|0.471|
|[[:human genes:s:sox7|SOX7]]|0.471|
|[[:human genes:o:opa1|OPA1]]|0.469|
|[[:human genes:h:hccs|HCCS]]|0.469|
|[[:human genes:t:trip12|TRIP12]]|0.467|
|[[:human genes:a:apaf1|APAF1]]|0.466|
|[[:human genes:f:fbxo11|FBXO11]]|0.465|
|[[:human genes:p:pmm2|PMM2]]|0.464|
|[[:human genes:k:kdsr|KDSR]]|0.463|
|[[:human genes:z:zmym2|ZMYM2]]|0.462|
|[[:human genes:c:cmtr1|CMTR1]]|0.46|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.459|
|[[:human genes:a:atf7ip|ATF7IP]]|0.457|
|[[:human genes:g:gmppb|GMPPB]]|0.457|
|[[:human genes:d:dpagt1|DPAGT1]]|0.455|
|[[:human genes:p:pdap1|PDAP1]]|0.45|
|[[:human genes:t:trim33|TRIM33]]|0.449|
|[[:human genes:h:hhex|HHEX]]|0.447|
|[[:human genes:s:serf2|SERF2]]|0.447|
|[[:human genes:d:ddx5|DDX5]]|0.447|
|[[:human genes:z:znf608|ZNF608]]|0.443|
|[[:human genes:e:erg|ERG]]|0.439|
|[[:human genes:m:med23|MED23]]|0.439|
|[[:human genes:v:vdac2|VDAC2]]|0.438|
|[[:human genes:s:ssb|SSB]]|0.438|
|[[:human genes:e:eny2|ENY2]]|0.438|
|[[:human genes:h:hars|HARS]]|0.438|
|[[:human genes:s:setdb1|SETDB1]]|0.434|
|[[:human genes:i:id4|ID4]]|0.432|
|[[:human genes:a:alg2|ALG2]]|0.432|
|[[:human genes:u:usp22|USP22]]|0.432|
|[[:human genes:o:otud5|OTUD5]]|0.432|
|[[:human genes:z:zbtb44|ZBTB44]]|0.431|
|[[:human genes:m:mllt1|MLLT1]]|0.431|
|[[:human genes:a:asb7|ASB7]]|0.43|
|[[:human genes:p:pdpk1|PDPK1]]|0.43|
|[[:human genes:c:cycs|CYCS]]|0.429|
|[[:human genes:m:meaf6|MEAF6]]|0.429|
|[[:human genes:m:march5|MARCH5]]|0.427|
|[[:human genes:d:diablo|DIABLO]]|0.426|
|[[:human genes:t:timm13|TIMM13]]|0.425|
|[[:human genes:u:ube2k|UBE2K]]|0.425|
|[[:human genes:d:dhx29|DHX29]]|0.424|
|[[:human genes:r:rtcb|RTCB]]|0.423|
|[[:human genes:c:cd81|CD81]]|0.422|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.422|
|[[:human genes:d:dr1|DR1]]|0.421|
|[[:human genes:p:pam16|PAM16]]|0.42|
|[[:human genes:t:tmem41b|TMEM41B]]|0.419|
|[[:human genes:c:cbx3|CBX3]]|0.419|
|[[:human genes:u:ubqln1|UBQLN1]]|0.417|
|[[:human genes:t:taf4|TAF4]]|0.413|
|[[:human genes:a:alg1|ALG1]]|0.411|
|[[:human genes:p:pdcd5|PDCD5]]|0.409|
|[[:human genes:w:wdr59|WDR59]]|0.409|
|[[:human genes:d:dnlz|DNLZ]]|0.408|
|[[:human genes:b:brd9|BRD9]]|0.407|
|[[:human genes:u:ube2l3|UBE2L3]]|0.407|
|[[:human genes:a:alg13|ALG13]]|0.407|
|[[:human genes:v:vmp1|VMP1]]|0.407|
|[[:human genes:t:ttc4|TTC4]]|0.406|
|[[:human genes:t:tti2|TTI2]]|0.406|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.406|
|[[:human genes:r:rpn1|RPN1]]|0.405|
|[[:human genes:s:sec63|SEC63]]|0.404|
|[[:human genes:c:crls1|CRLS1]]|0.404|
|[[:human genes:t:taz|TAZ]]|0.402|
|[[:human genes:a:atp2a2|ATP2A2]]|0.4|
|[[:human genes:e:exoc4|EXOC4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2153
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSD1 Expression in NALM6 Cells: 8.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>