======= NSUN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSUN3
  * **<color #00a2e8>Official Name</color>**: NOP2/Sun RNA methyltransferase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63899|63899]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H649|Q9H649]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSUN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSUN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617491|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879). {ECO:0000269|PubMed:27214402, ECO:0000269|PubMed:27356879, ECO:0000269|PubMed:27497299}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nol1 Nop2 Fmu|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA wobble base cytosine methylation|
|tRNA wobble cytosine modification|
|tRNA C5-cytosine methylation|
|tRNA (cytosine-5-)-methyltransferase activity|
|tRNA wobble base modification|
|regulation of mitochondrial translation|
|rRNA methylation|
|regulation of mitochondrial gene expression|
|rRNA modification|
|tRNA methylation|
|methyltransferase activity|
|mitochondrial large ribosomal subunit|
|tRNA binding|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|regulation of translation|
|mitochondrial matrix|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|RNA processing|
|mitochondrion|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.8|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.74|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.77|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.89|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.28|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rmnd1|RMND1]]|0.476|
|[[:human genes:f:fastkd2|FASTKD2]]|0.462|
|[[:human genes:g:grsf1|GRSF1]]|0.423|
|[[:human genes:m:mto1|MTO1]]|0.42|
|[[:human genes:m:mrps27|MRPS27]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2361
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSUN3 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>