======= NSUN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSUN4
  * **<color #00a2e8>Official Name</color>**: NOP2/Sun RNA methyltransferase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=387338|387338]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CB9|Q96CB9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSUN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSUN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615394|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4. {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:23022348}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nol1 Nop2 Fmu|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA (cytosine-C5-)-methyltransferase activity|
|mature ribosome assembly|
|small ribosomal subunit rRNA binding|
|positive regulation of mitochondrial translation|
|regulation of mitochondrial translation|
|rRNA methylation|
|regulation of mitochondrial gene expression|
|rRNA modification|
|methyltransferase activity|
|mitochondrial large ribosomal subunit|
|ribosome assembly|
|RNA methylation|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|regulation of translation|
|mitochondrial matrix|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|organelle assembly|
|cellular protein-containing complex assembly|
|RNA processing|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.73|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.74|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.75|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.78|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.07|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.21|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eral1|ERAL1]]|0.591|
|[[:human genes:p:pde12|PDE12]]|0.585|
|[[:human genes:p:pet112|PET112]]|0.583|
|[[:human genes:m:mtif2|MTIF2]]|0.569|
|[[:human genes:f:fastkd2|FASTKD2]]|0.547|
|[[:human genes:a:aars2|AARS2]]|0.543|
|[[:human genes:t:tfb1m|TFB1M]]|0.538|
|[[:human genes:m:malsu1|MALSU1]]|0.527|
|[[:human genes:a:acad9|ACAD9]]|0.523|
|[[:human genes:m:mettl17|METTL17]]|0.52|
|[[:human genes:n:nars2|NARS2]]|0.518|
|[[:human genes:n:nubpl|NUBPL]]|0.518|
|[[:human genes:r:rpusd3|RPUSD3]]|0.518|
|[[:human genes:g:grsf1|GRSF1]]|0.517|
|[[:human genes:p:prepl|PREPL]]|0.511|
|[[:human genes:p:pet117|PET117]]|0.51|
|[[:human genes:m:mcat|MCAT]]|0.507|
|[[:human genes:q:qrsl1|QRSL1]]|0.505|
|[[:human genes:d:ddx28|DDX28]]|0.503|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.499|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.49|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.488|
|[[:human genes:n:ndufb10|NDUFB10]]|0.488|
|[[:human genes:l:lars2|LARS2]]|0.487|
|[[:human genes:f:ftsj2|FTSJ2]]|0.481|
|[[:human genes:m:mrps18b|MRPS18B]]|0.479|
|[[:human genes:m:mto1|MTO1]]|0.478|
|[[:human genes:c:coa3|COA3]]|0.477|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.477|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.475|
|[[:human genes:m:mrpl49|MRPL49]]|0.474|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.473|
|[[:human genes:r:rmnd1|RMND1]]|0.472|
|[[:human genes:w:wars2|WARS2]]|0.466|
|[[:human genes:c:cars2|CARS2]]|0.463|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.462|
|[[:human genes:r:rars2|RARS2]]|0.461|
|[[:human genes:t:tsfm|TSFM]]|0.459|
|[[:human genes:n:ndufv2|NDUFV2]]|0.459|
|[[:human genes:m:mrps27|MRPS27]]|0.457|
|[[:human genes:s:sfxn4|SFXN4]]|0.454|
|[[:human genes:n:ndufb11|NDUFB11]]|0.453|
|[[:human genes:m:mars2|MARS2]]|0.451|
|[[:human genes:i:iba57|IBA57]]|0.45|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.447|
|[[:human genes:m:mrps21|MRPS21]]|0.446|
|[[:human genes:n:ndufa1|NDUFA1]]|0.446|
|[[:human genes:y:ybey|YBEY]]|0.446|
|[[:human genes:n:ndufb9|NDUFB9]]|0.444|
|[[:human genes:m:mrpl3|MRPL3]]|0.444|
|[[:human genes:m:mrpl45|MRPL45]]|0.443|
|[[:human genes:m:mrps12|MRPS12]]|0.443|
|[[:human genes:n:ndufb6|NDUFB6]]|0.442|
|[[:human genes:p:polg2|POLG2]]|0.44|
|[[:human genes:p:ptcd3|PTCD3]]|0.431|
|[[:human genes:t:tomm70a|TOMM70A]]|0.43|
|[[:human genes:n:ndufb7|NDUFB7]]|0.429|
|[[:human genes:i:ict1|ICT1]]|0.428|
|[[:human genes:p:polrmt|POLRMT]]|0.427|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.427|
|[[:human genes:m:mrpl43|MRPL43]]|0.426|
|[[:human genes:m:mipep|MIPEP]]|0.426|
|[[:human genes:p:prim1|PRIM1]]|0.425|
|[[:human genes:s:ssbp1|SSBP1]]|0.424|
|[[:human genes:n:ndufc1|NDUFC1]]|0.423|
|[[:human genes:m:mrps22|MRPS22]]|0.422|
|[[:human genes:n:ndufb4|NDUFB4]]|0.421|
|[[:human genes:c:cox11|COX11]]|0.421|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.421|
|[[:human genes:t:tars2|TARS2]]|0.419|
|[[:human genes:p:pars2|PARS2]]|0.419|
|[[:human genes:t:trit1|TRIT1]]|0.416|
|[[:human genes:g:gfm1|GFM1]]|0.416|
|[[:human genes:c:c1qbp|C1QBP]]|0.415|
|[[:human genes:n:ndufs2|NDUFS2]]|0.415|
|[[:human genes:c:cluh|CLUH]]|0.414|
|[[:human genes:m:mtg1|MTG1]]|0.414|
|[[:human genes:m:mrpl17|MRPL17]]|0.413|
|[[:human genes:e:ecsit|ECSIT]]|0.413|
|[[:human genes:m:mrps35|MRPS35]]|0.413|
|[[:human genes:p:polg|POLG]]|0.411|
|[[:human genes:m:mrpl40|MRPL40]]|0.41|
|[[:human genes:m:mrps25|MRPS25]]|0.409|
|[[:human genes:t:tmem261|TMEM261]]|0.409|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.404|
|[[:human genes:m:mettl1|METTL1]]|0.403|
|[[:human genes:n:ndufa11|NDUFA11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 202
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSUN4 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>