======= NTRK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NTRK3
  * **<color #00a2e8>Official Name</color>**: neurotrophic receptor tyrosine kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4916|4916]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16288|Q16288]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NTRK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NTRK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191316|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|LRR 4|
|ig|
|Pkinase Tyr|
|LRRNT|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by virus of host transcription|
|modulation of transcription in other organism involved in symbiotic interaction|
|modulation by symbiont of host transcription|
|positive regulation of axon extension involved in regeneration|
|positive regulation of sprouting of injured axon|
|modulation by virus of host gene expression|
|neurotrophin receptor activity|
|regulation of sprouting of injured axon|
|regulation of axon extension involved in regeneration|
|neurotrophin binding|
|positive regulation of neurotrophin TRK receptor signaling pathway|
|GPI-linked ephrin receptor activity|
|positive regulation of axon regeneration|
|positive regulation of neuron projection regeneration|
|neuronal action potential propagation|
|action potential propagation|
|regulation of postsynaptic density assembly|
|negative regulation of astrocyte differentiation|
|regulation of postsynaptic specialization assembly|
|regulation of postsynapse assembly|
|regulation of neurotrophin TRK receptor signaling pathway|
|regulation of excitatory synapse assembly|
|regulation of postsynaptic density organization|
|modulation by virus of host cellular process|
|positive regulation of actin cytoskeleton reorganization|
|response to corticosterone|
|regulation of axon regeneration|
|negative regulation of glial cell differentiation|
|positive regulation of positive chemotaxis|
|modulation by symbiont of host cellular process|
|regulation of positive chemotaxis|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|regulation of astrocyte differentiation|
|lens fiber cell differentiation|
|neurotrophin signaling pathway|
|regulation of neuron projection regeneration|
|regulation of presynapse assembly|
|Schwann cell development|
|regulation of presynapse organization|
|modulation by virus of host morphology or physiology|
|activation of protein kinase B activity|
|response to mineralocorticoid|
|neuron fate specification|
|Schwann cell differentiation|
|regulation of actin cytoskeleton reorganization|
|modification by symbiont of host morphology or physiology|
|negative regulation of gliogenesis|
|positive regulation of axon extension|
|positive regulation of phospholipase C activity|
|integral component of postsynaptic membrane|
|regulation of phospholipase C activity|
|response to axon injury|
|cellular response to nerve growth factor stimulus|
|cochlea development|
|response to nerve growth factor|
|transmembrane receptor protein tyrosine kinase activity|
|transmission of nerve impulse|
|mechanoreceptor differentiation|
|positive regulation of phospholipase activity|
|neuron fate commitment|
|positive regulation of response to wounding|
|p53 binding|
|positive regulation of synapse assembly|
|cellular response to retinoic acid|
|regulation of glial cell differentiation|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|peripheral nervous system development|
|lens development in camera-type eye|
|positive regulation of axonogenesis|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|ephrin receptor signaling pathway|
|cell fate specification|
|action potential|
|regulation of postsynapse organization|
|regulation of axon extension|
|activation of GTPase activity|
|regulation of lipase activity|
|regulation of synapse assembly|
|positive regulation of peptidyl-serine phosphorylation|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|response to retinoic acid|
|regulation of extent of cell growth|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of gliogenesis|
|neuron migration|
|regulation of phosphatidylinositol 3-kinase signaling|
|response to ethanol|
|multicellular organismal signaling|
|positive regulation of chemotaxis|
|regulation of peptidyl-serine phosphorylation|
|circadian rhythm|
|peptidyl-tyrosine phosphorylation|
|response to glucocorticoid|
|peptidyl-tyrosine modification|
|activation of MAPK activity|
|positive regulation of cell morphogenesis involved in differentiation|
|modification of morphology or physiology of other organism|
|interaction with host|
|response to corticosteroid|
|positive regulation of cell growth|
|regulation of response to wounding|
|glial cell differentiation|
|positive regulation of developmental growth|
|regulation of cell size|
|regulation of axonogenesis|
|inner ear development|
|response to ketone|
|receptor complex|
|cellular response to acid chemical|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|gliogenesis|
|regulation of synapse organization|
|positive regulation of cytoskeleton organization|
|regulation of organelle assembly|
|ear development|
|regulation of synapse structure or activity|
|response to alcohol|
|cell fate commitment|
|positive regulation of growth|
|positive regulation of MAP kinase activity|
|regulation of cellular response to growth factor stimulus|
|rhythmic process|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|axon|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|camera-type eye development|
|response to steroid hormone|
|activation of protein kinase activity|
|regulation of developmental growth|
|negative regulation of cell development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|glutamatergic synapse|
|eye development|
|visual system development|
|positive regulation of neuron differentiation|
|sensory system development|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|regulation of cell growth|
|regulation of membrane potential|
|negative regulation of phosphorylation|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|regulation of growth|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|viral process|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|symbiotic process|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14178
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NTRK3 Expression in NALM6 Cells: 2.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>