======= NUDT18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDT18
  * **<color #00a2e8>Official Name</color>**: nudix hydrolase 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79873|79873]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZVK8|Q6ZVK8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDT18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDT18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615791|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. {ECO:0000269|PubMed:22556419}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUDIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GDP catabolic process|
|deoxyribonucleoside diphosphate catabolic process|
|8-hydroxy-dADP phosphatase activity|
|dADP catabolic process|
|8-oxo-GDP phosphatase activity|
|dGDP catabolic process|
|purine deoxyribonucleoside diphosphate catabolic process|
|8-oxo-dGDP phosphatase activity|
|dADP metabolic process|
|dGDP metabolic process|
|purine ribonucleoside diphosphate catabolic process|
|guanosine-containing compound catabolic process|
|purine nucleoside diphosphate catabolic process|
|purine deoxyribonucleoside diphosphate metabolic process|
|deoxyribonucleoside diphosphate metabolic process|
|purine deoxyribonucleotide catabolic process|
|ribonucleoside diphosphate catabolic process|
|nucleoside diphosphate catabolic process|
|purine ribonucleoside catabolic process|
|purine nucleoside catabolic process|
|GDP metabolic process|
|purine deoxyribonucleotide metabolic process|
|deoxyribonucleotide catabolic process|
|deoxyribose phosphate catabolic process|
|ribonucleoside catabolic process|
|2-deoxyribonucleotide metabolic process|
|purine ribonucleotide catabolic process|
|deoxyribose phosphate metabolic process|
|ribonucleotide catabolic process|
|deoxyribonucleotide metabolic process|
|nucleoside catabolic process|
|guanosine-containing compound metabolic process|
|glycosyl compound catabolic process|
|purine nucleotide catabolic process|
|nucleobase-containing small molecule catabolic process|
|purine-containing compound catabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside diphosphate metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|purine nucleoside metabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|ribonucleoside metabolic process|
|nucleoside diphosphate metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|organophosphate catabolic process|
|glycosyl compound metabolic process|
|carbohydrate derivative catabolic process|
|magnesium ion binding|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.92|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.79|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.82|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.88|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.97|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.08|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10459
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDT18 Expression in NALM6 Cells: 1.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>