======= NUDT21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDT21
  * **<color #00a2e8>Official Name</color>**: nudix hydrolase 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11051|11051]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43809|O43809]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDT21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDT21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604978|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:20479262, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of pro-B cell differentiation|
|regulation of mRNA cleavage|
|positive regulation of mRNA cleavage|
|positive regulation of lymphoid progenitor cell differentiation|
|messenger ribonucleoprotein complex assembly|
|positive regulation of mRNA polyadenylation|
|mRNA alternative polyadenylation|
|mRNA cleavage factor complex|
|positive regulation of hematopoietic progenitor cell differentiation|
|paraspeckles|
|regulation of pro-B cell differentiation|
|AU-rich element binding|
|regulation of lymphoid progenitor cell differentiation|
|positive regulation of mRNA 3-end processing|
|pre-mRNA cleavage required for polyadenylation|
|mRNA cleavage involved in mRNA processing|
|mRNA cleavage and polyadenylation specificity factor complex|
|regulation of mRNA polyadenylation|
|positive regulation of stem cell differentiation|
|mRNA cleavage|
|mRNA 3-UTR AU-rich region binding|
|mRNA polyadenylation|
|regulation of mRNA 3-end processing|
|RNA polyadenylation|
|positive regulation of mRNA processing|
|protein heterotetramerization|
|termination of RNA polymerase II transcription|
|DNA-templated transcription, termination|
|hydrolase activity|
|positive regulation of mRNA metabolic process|
|mRNA 3-end processing|
|regulation of hematopoietic progenitor cell differentiation|
|protein heterooligomerization|
|histone deacetylase binding|
|regulation of stem cell differentiation|
|RNA 3-end processing|
|regulation of mRNA processing|
|protein tetramerization|
|microtubule organizing center|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|positive regulation of hemopoiesis|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nuclear body|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|chromatin binding|
|RNA splicing|
|regulation of hemopoiesis|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|transcription by RNA polymerase II|
|centrosome|
|protein complex oligomerization|
|posttranscriptional regulation of gene expression|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|protein homodimerization activity|
|positive regulation of cell differentiation|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|RNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.74|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.513|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 725/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDT21 Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>