======= NUDT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDT7
  * **<color #00a2e8>Official Name</color>**: nudix hydrolase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283927|283927]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0C024|P0C024]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609231|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'- phosphopantetheine. Has no activity toward NDP-sugars, CDP- alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUDIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coenzyme A catabolic process|
|CoA hydrolase activity|
|acetyl-CoA catabolic process|
|acetyl-CoA hydrolase activity|
|purine nucleoside bisphosphate catabolic process|
|nucleoside bisphosphate catabolic process|
|ribonucleoside bisphosphate catabolic process|
|m7G(5)pppN diphosphatase activity|
|coenzyme A metabolic process|
|snoRNA binding|
|coenzyme catabolic process|
|brown fat cell differentiation|
|acetyl-CoA metabolic process|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|purine nucleotide catabolic process|
|peroxisomal matrix|
|purine-containing compound catabolic process|
|sulfur compound catabolic process|
|cofactor catabolic process|
|manganese ion binding|
|nucleotide catabolic process|
|establishment of protein localization to peroxisome|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|peroxisomal transport|
|nucleoside phosphate catabolic process|
|peroxisome organization|
|nucleoside diphosphate metabolic process|
|fatty acid catabolic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|fat cell differentiation|
|peroxisome|
|monocarboxylic acid catabolic process|
|organophosphate catabolic process|
|ribonucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|carbohydrate derivative catabolic process|
|cellular lipid catabolic process|
|magnesium ion binding|
|coenzyme metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|lipid catabolic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein targeting|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|protein localization to organelle|
|molecular function|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|intracellular protein transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.612|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11096
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDT7 Expression in NALM6 Cells: 1.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>