======= NUMBL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUMBL
  * **<color #00a2e8>Official Name</color>**: NUMB like endocytic adaptor protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9253|9253]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6R0|Q9Y6R0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUMBL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUMBL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604018|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PTB|
|NumbF|
|PID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuroblast division in subventricular zone|
|forebrain neuroblast division|
|lateral ventricle development|
|neuronal stem cell division|
|neuroblast division|
|somatic stem cell division|
|ventricular system development|
|cell proliferation in forebrain|
|neuroblast proliferation|
|stem cell division|
|stem cell proliferation|
|forebrain generation of neurons|
|neural precursor cell proliferation|
|adherens junction organization|
|cell junction organization|
|telencephalon development|
|axonogenesis|
|forebrain development|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|cytokine-mediated signaling pathway|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|central nervous system development|
|cellular response to cytokine stimulus|
|neuron differentiation|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7288
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUMBL Expression in NALM6 Cells: 3.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>