======= NUP107 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP107
  * **<color #00a2e8>Official Name</color>**: nucleoporin 107
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57122|57122]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57740|P57740]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP107&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP107|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607617|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nup84 Nup100|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|
|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|
|nuclear pore outer ring|
|nuclear pore complex assembly|
|nuclear periphery|
|nuclear pore organization|
|pore complex assembly|
|structural constituent of nuclear pore|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|kinetochore|
|regulation of gene silencing by miRNA|
|female gonad development|
|regulation of carbohydrate catabolic process|
|condensed chromosome kinetochore|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|development of primary female sexual characteristics|
|protein import into nucleus|
|female sex differentiation|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|nephron development|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|nucleus organization|
|protein import|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|nuclear envelope|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|gonad development|
|development of primary sexual characteristics|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|sex differentiation|
|nuclear transport|
|kidney development|
|renal system development|
|peptidyl-lysine modification|
|urogenital system development|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|establishment of protein localization to organelle|
|developmental process involved in reproduction|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|chromosome organization|
|reproductive process|
|reproduction|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.12|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.97|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.85|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.71|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.71|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.72|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.83|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.84|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.85|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.93|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.472|
|[[:human genes:s:ssh2|SSH2]]|0.451|
|[[:human genes:n:nbpf16|NBPF16]]|0.438|
|[[:human genes:p:psmc6|PSMC6]]|0.437|
|[[:human genes:s:slc38a7|SLC38A7]]|0.437|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.435|
|[[:human genes:c:cbwd3|CBWD3]]|0.433|
|[[:human genes:o:ogfr|OGFR]]|0.433|
|[[:human genes:n:nbpf10|NBPF10]]|0.426|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.426|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.425|
|[[:human genes:c:cbwd5|CBWD5]]|0.425|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.425|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.424|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.423|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.42|
|[[:human genes:o:orc1|ORC1]]|0.418|
|[[:human genes:r:rbbp5|RBBP5]]|0.414|
|[[:human genes:p:prpf8|PRPF8]]|0.414|
|[[:human genes:n:nupl1|NUPL1]]|0.413|
|[[:human genes:p:polr2j3|POLR2J3]]|0.412|
|[[:human genes:v:vasn|VASN]]|0.41|
|[[:human genes:d:ddtl|DDTL]]|0.409|
|[[:human genes:c:cdc45|CDC45]]|0.408|
|[[:human genes:c:cope|COPE]]|0.404|
|[[:human genes:s:scaf1|SCAF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 153/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|5/28|
|bone|5/26|
|breast|7/33|
|central nervous system|12/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|1/21|
|liver|2/20|
|lung|18/75|
|lymphocyte|4/16|
|ovary|5/26|
|pancreas|9/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1185
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP107 Expression in NALM6 Cells: 7.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>