======= NVL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NVL
  * **<color #00a2e8>Official Name</color>**: nuclear VCP like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4931|4931]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15381|O15381]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NVL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NVL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602426|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). May play a role in 60S ribosomal subunit biogenesis (PubMed:15469983, PubMed:16782053). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
|RuvB N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome binding|
|regulation of protein localization to nucleolus|
|nuclear exosome (RNase complex)|
|telomerase holoenzyme complex|
|positive regulation of telomerase activity|
|regulation of telomerase activity|
|positive regulation of DNA biosynthetic process|
|ribosomal large subunit biogenesis|
|positive regulation of protein binding|
|regulation of DNA biosynthetic process|
|regulation of protein localization to nucleus|
|positive regulation of binding|
|positive regulation of DNA metabolic process|
|rRNA processing|
|regulation of protein binding|
|rRNA metabolic process|
|ATPase activity|
|ribosome biogenesis|
|regulation of DNA metabolic process|
|regulation of binding|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|regulation of cellular protein localization|
|positive regulation of transferase activity|
|nucleolus|
|RNA processing|
|regulation of cellular localization|
|regulation of transferase activity|
|regulation of protein localization|
|RNA binding|
|positive regulation of catalytic activity|
|ATP binding|
|RNA metabolic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.03|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.87|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.7|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.93|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.97|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.19|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 672/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|23/28|
|bone|25/26|
|breast|30/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|18/21|
|liver|19/20|
|lung|71/75|
|lymphocyte|11/16|
|ovary|23/26|
|pancreas|19/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 274
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NVL Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>