======= OBSCN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OBSCN
  * **<color #00a2e8>Official Name</color>**: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84033|84033]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VST9|Q5VST9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OBSCN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OBSCN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608616|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|RhoGEF|
|fn3|
|V-set|
|Pkinase Tyr|
|ig|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to M-band|
|titin binding|
|phosphatidylinositol-5-phosphate binding|
|ankyrin binding|
|M band|
|myofibril|
|phosphatidylinositol-3,4-bisphosphate binding|
|phosphatidylinositol-4-phosphate binding|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|phosphatidylinositol-3-phosphate binding|
|sarcomere organization|
|structural constituent of muscle|
|myofibril assembly|
|Rho guanyl-nucleotide exchange factor activity|
|phosphatidylinositol-4,5-bisphosphate binding|
|sarcolemma|
|cellular component assembly involved in morphogenesis|
|actomyosin structure organization|
|Z disc|
|striated muscle cell development|
|regulation of Rho protein signal transduction|
|muscle cell development|
|striated muscle cell differentiation|
|calmodulin binding|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|nuclear body|
|regulation of small GTPase mediated signal transduction|
|protein serine/threonine kinase activity|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|actin filament-based process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|protein localization to organelle|
|organelle assembly|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|protein phosphorylation|
|cytoskeleton organization|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|regulation of cell death|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9218
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OBSCN Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>