======= OCLN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OCLN
  * **<color #00a2e8>Official Name</color>**: occludin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100506658|100506658]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16625|Q16625]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OCLN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OCLN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602876|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Occludin ELL|
|MARVEL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to interleukin-18|
|apicolateral plasma membrane|
|regulation of bicellular tight junction assembly|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|apical junction assembly|
|lateral plasma membrane|
|endocytic vesicle|
|regulation of cell junction assembly|
|cell-cell junction assembly|
|bicellular tight junction|
|cell-cell junction organization|
|cell junction assembly|
|cell-cell junction|
|cell junction organization|
|cellular response to tumor necrosis factor|
|protein domain specific binding|
|cytoplasmic vesicle|
|response to tumor necrosis factor|
|apical plasma membrane|
|cell junction|
|protein-containing complex|
|regulation of cellular component biogenesis|
|cellular response to cytokine stimulus|
|response to cytokine|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10257
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OCLN Expression in NALM6 Cells: 4.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>