======= ODC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ODC1
  * **<color #00a2e8>Official Name</color>**: ornithine decarboxylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4953|4953]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11926|P11926]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ODC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ODC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. {ECO:0000269|PubMed:17900240}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Orn Arg deC N|
|Orn DAP Arg deC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ornithine decarboxylase activity|
|putrescine biosynthetic process from ornithine|
|putrescine biosynthetic process|
|putrescine metabolic process|
|ornithine metabolic process|
|polyamine biosynthetic process|
|polyamine metabolic process|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|regulation of cellular amino acid metabolic process|
|amine metabolic process|
|regulation of cellular amine metabolic process|
|regulation of cellular ketone metabolic process|
|ammonium ion metabolic process|
|alpha-amino acid metabolic process|
|kidney development|
|response to virus|
|renal system development|
|cellular amino acid metabolic process|
|urogenital system development|
|regulation of protein catabolic process|
|regulation of small molecule metabolic process|
|cellular component|
|perinuclear region of cytoplasm|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-4.41|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-4.41|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.99|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.77|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.51|
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.41|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-2.23|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.15|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-2.11|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.98|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.97|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.95|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.9|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.88|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.87|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.75|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.72|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.7|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.7|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.71|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.73|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.73|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.74|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.87|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.88|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.89|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.9|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.9|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.92|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.93|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.93|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.94|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.95|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.02|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.03|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.03|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.08|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.08|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.1|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.1|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.1|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.11|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.16|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.17|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.17|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.18|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.23|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.32|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.33|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.45|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.46|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.63|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.73|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.98|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.26|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.36|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|3.52|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.55|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|3.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:azin1|AZIN1]]|0.477|
|[[:human genes:s:srm|SRM]]|0.437|
|[[:human genes:v:vps35|VPS35]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7976
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ODC1 Expression in NALM6 Cells: 9.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>