======= OPRL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OPRL1
  * **<color #00a2e8>Official Name</color>**: opioid related nociceptin receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4987|4987]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41146|P41146]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OPRL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OPRL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602548|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srv|
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nociceptin receptor activity|
|positive regulation of gastric acid secretion|
|conditioned place preference|
|regulation of locomotor rhythm|
|positive regulation of sensory perception of pain|
|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|opioid receptor signaling pathway|
|positive regulation of digestive system process|
|regulation of gastric acid secretion|
|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|negative regulation of voltage-gated calcium channel activity|
|positive regulation of urine volume|
|estrous cycle|
|regulation of urine volume|
|neuropeptide binding|
|negative regulation of cAMP-mediated signaling|
|eating behavior|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|negative regulation of calcium ion transmembrane transporter activity|
|regulation of voltage-gated calcium channel activity|
|regulation of sensory perception of pain|
|negative regulation of calcium ion transmembrane transport|
|regulation of sensory perception|
|regulation of digestive system process|
|negative regulation of cation channel activity|
|negative regulation of blood pressure|
|negative regulation of G protein-coupled receptor signaling pathway|
|regulation of cAMP-mediated signaling|
|peptide binding|
|negative regulation of calcium ion transport|
|positive regulation of nervous system process|
|ovulation cycle|
|negative regulation of ion transmembrane transporter activity|
|regulation of behavior|
|sensory perception of pain|
|associative learning|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|feeding behavior|
|regulation of calcium ion transmembrane transporter activity|
|negative regulation of ion transmembrane transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|neuropeptide signaling pathway|
|renal system process|
|regulation of circadian rhythm|
|negative regulation of transmembrane transport|
|response to estradiol|
|regulation of nervous system process|
|regulation of G protein-coupled receptor signaling pathway|
|learning|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|regulation of cation channel activity|
|regulation of blood pressure|
|protein C-terminus binding|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|cytoplasmic vesicle|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|rhythmic process|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|cognition|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|negative regulation of intracellular signal transduction|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|sensory perception|
|positive regulation of transport|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of multicellular organismal process|
|regulation of intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.04|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.94|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.9|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10047
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OPRL1 Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>