======= ORMDL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ORMDL3
  * **<color #00a2e8>Official Name</color>**: ORMDL sphingolipid biosynthesis regulator 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=94103|94103]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N138|Q8N138]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ORMDL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ORMDL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610075|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. {ECO:0000269|PubMed:20182505}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ORMDL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular sphingolipid homeostasis|
|SPOTS complex|
|negative regulation of ceramide biosynthetic process|
|negative regulation of sphingolipid biosynthetic process|
|regulation of sphingolipid biosynthetic process|
|regulation of membrane lipid metabolic process|
|regulation of ceramide biosynthetic process|
|negative regulation of lipid biosynthetic process|
|negative regulation of lipid metabolic process|
|ceramide metabolic process|
|specific granule membrane|
|secretory granule membrane|
|lipid homeostasis|
|negative regulation of cellular amide metabolic process|
|sphingolipid metabolic process|
|regulation of lipid biosynthetic process|
|membrane lipid metabolic process|
|regulation of lipid metabolic process|
|regulation of cellular amide metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|cellular homeostasis|
|leukocyte activation|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|cell activation|
|immune effector process|
|chemical homeostasis|
|secretion|
|lipid metabolic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|homeostatic process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.73|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.76|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.8|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4445
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ORMDL3 Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>