======= OTX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OTX1
  * **<color #00a2e8>Official Name</color>**: orthodenticle homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5013|5013]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32242|P32242]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OTX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OTX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600036|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|TF Otx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diencephalon morphogenesis|
|forebrain morphogenesis|
|brain morphogenesis|
|diencephalon development|
|midbrain development|
|inner ear morphogenesis|
|metencephalon development|
|ear morphogenesis|
|hindbrain development|
|inner ear development|
|anterior/posterior pattern specification|
|ear development|
|sensory organ morphogenesis|
|embryonic organ morphogenesis|
|regionalization|
|forebrain development|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|embryonic morphogenesis|
|brain development|
|head development|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|1.73|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.83|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.87|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.89|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.95|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6752
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OTX1 Expression in NALM6 Cells: 2.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>