======= OVOL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OVOL2
  * **<color #00a2e8>Official Name</color>**: ovo like zinc finger 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58495|58495]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRP0|Q9BRP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OVOL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OVOL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616441|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). {ECO:0000250|UniProtKB:Q8CIV7, ECO:0000269|PubMed:19700410}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endocardium formation|
|endocardium morphogenesis|
|neural fold formation|
|endocardium development|
|negative regulation of stem cell proliferation|
|heart trabecula formation|
|positive regulation of keratinocyte differentiation|
|embryonic digestive tract morphogenesis|
|morphogenesis of an epithelial fold|
|labyrinthine layer blood vessel development|
|trabecula formation|
|regulation of SMAD protein signal transduction|
|positive regulation of epidermal cell differentiation|
|negative regulation of epithelial to mesenchymal transition|
|placenta blood vessel development|
|heart trabecula morphogenesis|
|regulation of keratinocyte proliferation|
|embryonic digestive tract development|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|trabecula morphogenesis|
|labyrinthine layer development|
|digestive tract morphogenesis|
|neural crest cell migration|
|positive regulation of epithelial cell differentiation|
|heart looping|
|regulation of epidermal cell differentiation|
|regulation of stem cell proliferation|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube development|
|neural crest cell development|
|dorsal/ventral pattern formation|
|stem cell development|
|regulation of epithelial to mesenchymal transition|
|mesenchymal cell development|
|regulation of epidermis development|
|embryonic placenta development|
|neural crest cell differentiation|
|primary neural tube formation|
|neural tube formation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|embryonic epithelial tube formation|
|specification of symmetry|
|cardiac chamber morphogenesis|
|digestive tract development|
|epithelial tube formation|
|regulation of epithelial cell differentiation|
|digestive system development|
|morphogenesis of embryonic epithelium|
|tube formation|
|placenta development|
|cellular response to transforming growth factor beta stimulus|
|mesenchymal cell differentiation|
|stem cell differentiation|
|neural tube development|
|response to transforming growth factor beta|
|cardiac chamber development|
|ameboidal-type cell migration|
|mesenchyme development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|heart morphogenesis|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|epidermal cell differentiation|
|angiogenesis|
|regionalization|
|regulation of epithelial cell proliferation|
|in utero embryonic development|
|chromatin binding|
|blood vessel morphogenesis|
|epidermis development|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|cell motility|
|localization of cell|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12354
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.66 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OVOL2 Expression in NALM6 Cells: -1.66'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>