======= OXA1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OXA1L
  * **<color #00a2e8>Official Name</color>**: OXA1L mitochondrial inner membrane protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5018|5018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15070|Q15070]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OXA1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OXA1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601066|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. {ECO:0000269|PubMed:17936786, ECO:0000269|PubMed:7991568}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|60KD IMP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|membrane insertase activity|
|protein insertion into membrane from inner side|
|protein insertion into mitochondrial inner membrane from matrix|
|mitochondrial ribosome binding|
|mitochondrial proton-transporting ATP synthase complex assembly|
|proton-transporting ATP synthase complex assembly|
|integral component of mitochondrial membrane|
|protein insertion into mitochondrial inner membrane|
|proton-transporting two-sector ATPase complex assembly|
|mitochondrial respirasome|
|establishment of protein localization to mitochondrial membrane|
|negative regulation of ATPase activity|
|mitochondrial respiratory chain complex IV assembly|
|protein insertion into mitochondrial membrane|
|negative regulation of oxidoreductase activity|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|integral component of mitochondrial inner membrane|
|protein insertion into membrane|
|inner mitochondrial membrane organization|
|protein targeting to mitochondrion|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|aerobic respiration|
|regulation of ATPase activity|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|regulation of oxidoreductase activity|
|mitochondrial respiratory chain complex assembly|
|translational termination|
|mitochondrial membrane|
|mitochondrial translation|
|translational elongation|
|mitochondrial membrane organization|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein tetramerization|
|cellular respiration|
|mitochondrial transport|
|energy derivation by oxidation of organic compounds|
|protein-containing complex disassembly|
|establishment of protein localization to membrane|
|protein targeting|
|mitochondrial matrix|
|translation|
|cellular component disassembly|
|peptide biosynthetic process|
|generation of precursor metabolites and energy|
|establishment of protein localization to organelle|
|mitochondrion organization|
|negative regulation of hydrolase activity|
|protein localization to membrane|
|protein complex oligomerization|
|amide biosynthetic process|
|peptide metabolic process|
|protein-containing complex|
|protein localization to organelle|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|cellular protein-containing complex assembly|
|membrane organization|
|protein homodimerization activity|
|oxidation-reduction process|
|intracellular protein transport|
|negative regulation of molecular function|
|mitochondrion|
|regulation of hydrolase activity|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.76|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.81|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1610
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OXA1L Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>