======= OXCT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OXCT1
  * **<color #00a2e8>Official Name</color>**: 3-oxoacid CoA-transferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5019|5019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55809|P55809]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OXCT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OXCT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601424|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CoA trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-oxoacid CoA-transferase activity|
|ketone body catabolic process|
|ketone catabolic process|
|cellular ketone body metabolic process|
|fatty acid derivative catabolic process|
|ketone body metabolic process|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|adipose tissue development|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|response to activity|
|cellular ketone metabolic process|
|positive regulation of insulin secretion|
|positive regulation of peptide hormone secretion|
|response to ethanol|
|positive regulation of hormone secretion|
|drug catabolic process|
|fatty acid derivative metabolic process|
|regulation of insulin secretion|
|response to starvation|
|regulation of peptide hormone secretion|
|response to nutrient|
|connective tissue development|
|response to alcohol|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|response to antibiotic|
|mitochondrial matrix|
|positive regulation of secretion by cell|
|generation of precursor metabolites and energy|
|positive regulation of protein transport|
|positive regulation of secretion|
|small molecule catabolic process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|response to nutrient levels|
|drug metabolic process|
|response to toxic substance|
|heart development|
|response to extracellular stimulus|
|regulation of hormone levels|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|circulatory system development|
|protein homodimerization activity|
|response to hormone|
|regulation of cellular localization|
|central nervous system development|
|positive regulation of transport|
|response to drug|
|regulation of protein localization|
|mitochondrion|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6599
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OXCT1 Expression in NALM6 Cells: 7.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>