======= P2RX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RX1
  * **<color #00a2e8>Official Name</color>**: purinergic receptor P2X 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5023|5023]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51575|P51575]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P2X receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serotonin production involved in inflammatory response|
|serotonin secretion by platelet|
|serotonin secretion|
|serotonin secretion involved in inflammatory response|
|serotonin transport|
|purinergic nucleotide receptor activity|
|ATP-gated ion channel activity|
|extracellularly ATP-gated cation channel activity|
|regulation of vascular smooth muscle contraction|
|insemination|
|integral component of presynaptic active zone membrane|
|copulation|
|integral component of nuclear inner membrane|
|production of molecular mediator involved in inflammatory response|
|cation channel activity|
|regulation of presynaptic cytosolic calcium ion concentration|
|purinergic nucleotide receptor signaling pathway|
|monoamine transport|
|purinergic receptor signaling pathway|
|neuronal action potential|
|synaptic transmission, glutamatergic|
|response to ATP|
|mating|
|neuron cellular homeostasis|
|integral component of postsynaptic membrane|
|ceramide biosynthetic process|
|ammonium transport|
|transmission of nerve impulse|
|regulation of vasoconstriction|
|regulation of smooth muscle contraction|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|exocytic process|
|regulation of synaptic vesicle exocytosis|
|ceramide metabolic process|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|sphingolipid biosynthetic process|
|specific granule membrane|
|action potential|
|secretory granule membrane|
|regulation of postsynaptic membrane potential|
|regulation of neurotransmitter secretion|
|protein heterooligomerization|
|regulation of synaptic vesicle cycle|
|platelet degranulation|
|membrane lipid biosynthetic process|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|multicellular organismal signaling|
|response to organophosphorus|
|organic hydroxy compound transport|
|platelet activation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of neurotransmitter transport|
|positive regulation of cysteine-type endopeptidase activity|
|response to purine-containing compound|
|sphingolipid metabolic process|
|regulation of muscle contraction|
|regulation of regulated secretory pathway|
|vascular process in circulatory system|
|positive regulation of endopeptidase activity|
|neurotransmitter transport|
|regulation of blood pressure|
|positive regulation of peptidase activity|
|membrane lipid metabolic process|
|multi-multicellular organism process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to nutrient|
|regulation of exocytosis|
|membrane raft|
|regulation of muscle system process|
|regulation of cysteine-type endopeptidase activity|
|regulation of calcium ion transport|
|positive regulation of ion transport|
|regulation of blood circulation|
|blood coagulation|
|coagulation|
|hemostasis|
|neuron projection|
|regulation of cytosolic calcium ion concentration|
|protein homooligomerization|
|anatomical structure homeostasis|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|regulation of metal ion transport|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|regulation of endopeptidase activity|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|inflammatory response|
|response to nutrient levels|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|amide biosynthetic process|
|response to extracellular stimulus|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|response to wounding|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|regulation of system process|
|protein-containing complex|
|cation transmembrane transport|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of ion transport|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cellular amide metabolic process|
|exocytosis|
|regulation of secretion|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|ion transmembrane transport|
|cellular lipid metabolic process|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|programmed cell death|
|cell activation|
|response to nitrogen compound|
|cell death|
|immune effector process|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|lipid metabolic process|
|regulation of hydrolase activity|
|transmembrane transport|
|defense response|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|ATP binding|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.94|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8084
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RX1 Expression in NALM6 Cells: 3.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>