======= P2RX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RX5
  * **<color #00a2e8>Official Name</color>**: purinergic receptor P2X 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5026|5026]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q93086|Q93086]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602836|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P2X receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|purinergic nucleotide receptor activity|
|extracellularly ATP-gated cation channel activity|
|ATP-gated ion channel activity|
|integral component of nuclear inner membrane|
|purinergic nucleotide receptor signaling pathway|
|ion channel activity|
|purinergic receptor signaling pathway|
|response to ATP|
|positive regulation of calcium-mediated signaling|
|positive regulation of calcium ion transport into cytosol|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|postsynapse|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|regulation of postsynaptic membrane potential|
|positive regulation of calcium ion transport|
|response to organophosphorus|
|transmembrane signaling receptor activity|
|response to purine-containing compound|
|response to nutrient|
|regulation of calcium ion transport|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of cytosolic calcium ion concentration|
|regulation of metal ion transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|response to nutrient levels|
|response to extracellular stimulus|
|cellular metal ion homeostasis|
|response to wounding|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|positive regulation of intracellular signal transduction|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.96|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RX5 Expression in NALM6 Cells: 1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>