======= PAF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAF1
  * **<color #00a2e8>Official Name</color>**: PAF1 homolog, Paf1/RNA polymerase II complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54623|54623]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N7H5|Q8N7H5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610506|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Paf1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cdc73/Paf1 complex|
|histone H2B ubiquitination|
|positive regulation of mRNA 3-end processing|
|endodermal cell fate commitment|
|nucleosome positioning|
|positive regulation of transcription elongation from RNA polymerase II promoter|
|transcriptionally active chromatin|
|mRNA polyadenylation|
|cell fate commitment involved in formation of primary germ layer|
|regulation of mRNA 3-end processing|
|histone monoubiquitination|
|RNA polyadenylation|
|regulation of transcription elongation from RNA polymerase II promoter|
|positive regulation of mRNA processing|
|positive regulation of DNA-templated transcription, elongation|
|RNA polymerase II complex binding|
|positive regulation of histone methylation|
|histone ubiquitination|
|endodermal cell differentiation|
|endoderm formation|
|positive regulation of cell cycle G1/S phase transition|
|regulation of DNA-templated transcription, elongation|
|protein monoubiquitination|
|regulation of histone methylation|
|endoderm development|
|transcription elongation from RNA polymerase II promoter|
|negative regulation of myeloid cell differentiation|
|positive regulation of mRNA metabolic process|
|mRNA 3-end processing|
|DNA-templated transcription, elongation|
|positive regulation of histone modification|
|positive regulation of cell cycle phase transition|
|positive regulation of chromatin organization|
|formation of primary germ layer|
|chromatin assembly|
|RNA 3-end processing|
|stem cell population maintenance|
|negative regulation of hemopoiesis|
|maintenance of cell number|
|regulation of mRNA processing|
|regulation of histone modification|
|chromatin assembly or disassembly|
|nucleosome organization|
|gastrulation|
|protein localization to nucleus|
|regulation of cell cycle G1/S phase transition|
|positive regulation of chromosome organization|
|DNA packaging|
|cellular response to lipopolysaccharide|
|regulation of chromatin organization|
|cellular response to molecule of bacterial origin|
|cellular response to biotic stimulus|
|regulation of myeloid cell differentiation|
|protein-DNA complex subunit organization|
|cell fate commitment|
|positive regulation of cell cycle process|
|DNA conformation change|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|histone modification|
|covalent chromatin modification|
|positive regulation of cell cycle|
|chromatin binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|negative regulation of immune system process|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|mRNA processing|
|transcription by RNA polymerase II|
|cellular response to lipid|
|cell junction|
|embryonic morphogenesis|
|positive regulation of organelle organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|protein ubiquitination|
|response to bacterium|
|mRNA metabolic process|
|chromatin organization|
|negative regulation of cell differentiation|
|protein localization to organelle|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|embryo development|
|protein modification by small protein conjugation or removal|
|cellular response to oxygen-containing compound|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.15|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.06|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.99|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.89|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.74|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.72|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.7|
|[[:results:exp303|39°C R06 exp303]]|1.71|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.72|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.72|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.73|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.73|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.75|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.76|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.77|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.85|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.85|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.87|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.88|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.89|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.9|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.9|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.91|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.91|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.94|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.94|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.96|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.04|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.06|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.14|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.23|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.28|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.41|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.76|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.567|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.556|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.543|
|[[:human genes:c:ctr9|CTR9]]|0.537|
|[[:human genes:c:chd4|CHD4]]|0.534|
|[[:human genes:c:cdc73|CDC73]]|0.533|
|[[:human genes:v:vasn|VASN]]|0.523|
|[[:human genes:p:pan3|PAN3]]|0.516|
|[[:human genes:t:tceb3c|TCEB3C]]|0.516|
|[[:human genes:k:krt78|KRT78]]|0.509|
|[[:human genes:c:c14orf93|C14orf93]]|0.505|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.501|
|[[:human genes:o:orc1|ORC1]]|0.5|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.5|
|[[:human genes:n:narfl|NARFL]]|0.497|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.493|
|[[:human genes:s:sf3a3|SF3A3]]|0.493|
|[[:human genes:r:rps9|RPS9]]|0.493|
|[[:human genes:p:psmb3|PSMB3]]|0.492|
|[[:human genes:e:exosc9|EXOSC9]]|0.49|
|[[:human genes:p:psmd1|PSMD1]]|0.489|
|[[:human genes:c:cdca3|CDCA3]]|0.487|
|[[:human genes:n:npipb5|NPIPB5]]|0.487|
|[[:human genes:c:cope|COPE]]|0.483|
|[[:human genes:p:psmc2|PSMC2]]|0.483|
|[[:human genes:z:znf106|ZNF106]]|0.482|
|[[:human genes:z:zfand5|ZFAND5]]|0.482|
|[[:human genes:c:cep192|CEP192]]|0.48|
|[[:human genes:a:ankle2|ANKLE2]]|0.478|
|[[:human genes:s:snrnp70|SNRNP70]]|0.478|
|[[:human genes:d:dido1|DIDO1]]|0.477|
|[[:human genes:i:ik|IK]]|0.477|
|[[:human genes:c:copb1|COPB1]]|0.475|
|[[:human genes:s:smg7|SMG7]]|0.475|
|[[:human genes:s:sf3a1|SF3A1]]|0.474|
|[[:human genes:m:mt1e|MT1E]]|0.472|
|[[:human genes:m:myo1h|MYO1H]]|0.472|
|[[:human genes:p:pole|POLE]]|0.471|
|[[:human genes:c:ckap5|CKAP5]]|0.47|
|[[:human genes:a:arcn1|ARCN1]]|0.469|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.468|
|[[:human genes:d:ddtl|DDTL]]|0.467|
|[[:human genes:r:rps2|RPS2]]|0.466|
|[[:human genes:t:tsg101|TSG101]]|0.464|
|[[:human genes:o:orc6|ORC6]]|0.463|
|[[:human genes:c:copg1|COPG1]]|0.462|
|[[:human genes:r:rbm39|RBM39]]|0.461|
|[[:human genes:r:rrp15|RRP15]]|0.459|
|[[:human genes:g:golga8o|GOLGA8O]]|0.458|
|[[:human genes:c:ccna2|CCNA2]]|0.458|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.457|
|[[:human genes:p:psma6|PSMA6]]|0.456|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.456|
|[[:human genes:z:znf148|ZNF148]]|0.455|
|[[:human genes:p:pola1|POLA1]]|0.455|
|[[:human genes:p:psmc5|PSMC5]]|0.454|
|[[:human genes:s:snrpa1|SNRPA1]]|0.453|
|[[:human genes:i:iscu|ISCU]]|0.452|
|[[:human genes:n:nbpf10|NBPF10]]|0.451|
|[[:human genes:u:upf1|UPF1]]|0.451|
|[[:human genes:n:nop16|NOP16]]|0.45|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.449|
|[[:human genes:x:xylt2|XYLT2]]|0.449|
|[[:human genes:e:eif4a3|EIF4A3]]|0.448|
|[[:human genes:p:psmd11|PSMD11]]|0.448|
|[[:human genes:p:polr2j3|POLR2J3]]|0.447|
|[[:human genes:a:aamp|AAMP]]|0.446|
|[[:human genes:l:lrr1|LRR1]]|0.446|
|[[:human genes:s:supt6h|SUPT6H]]|0.445|
|[[:human genes:p:psmd7|PSMD7]]|0.444|
|[[:human genes:p:pola2|POLA2]]|0.444|
|[[:human genes:i:ints5|INTS5]]|0.443|
|[[:human genes:p:psmd3|PSMD3]]|0.443|
|[[:human genes:a:adrm1|ADRM1]]|0.443|
|[[:human genes:t:ticrr|TICRR]]|0.443|
|[[:human genes:r:rpl35|RPL35]]|0.442|
|[[:human genes:r:rps3|RPS3]]|0.441|
|[[:human genes:z:znf830|ZNF830]]|0.441|
|[[:human genes:n:nupl1|NUPL1]]|0.441|
|[[:human genes:p:pan2|PAN2]]|0.441|
|[[:human genes:s:slc4a1|SLC4A1]]|0.44|
|[[:human genes:s:supt5h|SUPT5H]]|0.44|
|[[:human genes:r:rps19|RPS19]]|0.439|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.439|
|[[:human genes:p:psmd14|PSMD14]]|0.439|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.439|
|[[:human genes:c:ccdc116|CCDC116]]|0.439|
|[[:human genes:e:exosc6|EXOSC6]]|0.439|
|[[:human genes:u:uqcrh|UQCRH]]|0.438|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.438|
|[[:human genes:s:setd1a|SETD1A]]|0.437|
|[[:human genes:m:myt1l|MYT1L]]|0.437|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.437|
|[[:human genes:p:pwp2|PWP2]]|0.437|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.436|
|[[:human genes:p:psmc6|PSMC6]]|0.436|
|[[:human genes:n:nup205|NUP205]]|0.436|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.436|
|[[:human genes:c:chaf1a|CHAF1A]]|0.434|
|[[:human genes:n:ncl|NCL]]|0.432|
|[[:human genes:s:sap30bp|SAP30BP]]|0.432|
|[[:human genes:t:tfip11|TFIP11]]|0.432|
|[[:human genes:d:dhfr|DHFR]]|0.431|
|[[:human genes:d:dtl|DTL]]|0.431|
|[[:human genes:b:bod1l1|BOD1L1]]|0.43|
|[[:human genes:r:rps12|RPS12]]|0.43|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.429|
|[[:human genes:p:psmb2|PSMB2]]|0.429|
|[[:human genes:n:nup160|NUP160]]|0.428|
|[[:human genes:s:sf3b2|SF3B2]]|0.428|
|[[:human genes:r:rad21|RAD21]]|0.428|
|[[:human genes:c:clpx|CLPX]]|0.427|
|[[:human genes:c:copa|COPA]]|0.427|
|[[:human genes:n:npipb8|NPIPB8]]|0.427|
|[[:human genes:a:abhd8|ABHD8]]|0.426|
|[[:human genes:c:cgb2|CGB2]]|0.426|
|[[:human genes:r:rrn3|RRN3]]|0.426|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.424|
|[[:human genes:i:isy1|ISY1]]|0.424|
|[[:human genes:r:rpl6|RPL6]]|0.424|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.424|
|[[:human genes:p:pdcd11|PDCD11]]|0.423|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.423|
|[[:human genes:w:wdr75|WDR75]]|0.422|
|[[:human genes:n:nol12|NOL12]]|0.422|
|[[:human genes:c:cwc22|CWC22]]|0.422|
|[[:human genes:p:pcf11|PCF11]]|0.421|
|[[:human genes:r:rrp7a|RRP7A]]|0.421|
|[[:human genes:r:rpl38|RPL38]]|0.42|
|[[:human genes:h:hivep3|HIVEP3]]|0.42|
|[[:human genes:z:znf655|ZNF655]]|0.42|
|[[:human genes:c:cdc6|CDC6]]|0.419|
|[[:human genes:t:taf15|TAF15]]|0.419|
|[[:human genes:g:gon4l|GON4L]]|0.419|
|[[:human genes:c:col2a1|COL2A1]]|0.418|
|[[:human genes:c:cln6|CLN6]]|0.418|
|[[:human genes:r:rpsa|RPSA]]|0.418|
|[[:human genes:s:ssh2|SSH2]]|0.417|
|[[:human genes:c:cbwd3|CBWD3]]|0.416|
|[[:human genes:e:exosc5|EXOSC5]]|0.415|
|[[:human genes:a:aqr|AQR]]|0.415|
|[[:human genes:f:fam231c|FAM231C]]|0.415|
|[[:human genes:f:fam231a|FAM231A]]|0.415|
|[[:human genes:p:psmc1|PSMC1]]|0.415|
|[[:human genes:p:polr2a|POLR2A]]|0.415|
|[[:human genes:m:myo18a|MYO18A]]|0.413|
|[[:human genes:t:tagln|TAGLN]]|0.412|
|[[:human genes:s:slc6a17|SLC6A17]]|0.412|
|[[:human genes:s:scaf1|SCAF1]]|0.41|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.41|
|[[:human genes:n:nhp2l1|NHP2L1]]|0.409|
|[[:human genes:d:ddt|DDT]]|0.409|
|[[:human genes:c:cnot1|CNOT1]]|0.408|
|[[:human genes:c:copb2|COPB2]]|0.407|
|[[:human genes:b:brd2|BRD2]]|0.406|
|[[:human genes:t:top1mt|TOP1MT]]|0.406|
|[[:human genes:c:cbwd5|CBWD5]]|0.406|
|[[:human genes:r:riok2|RIOK2]]|0.405|
|[[:human genes:c:cdt1|CDT1]]|0.405|
|[[:human genes:m:myb|MYB]]|0.405|
|[[:human genes:r:rps28|RPS28]]|0.404|
|[[:human genes:o:osbp|OSBP]]|0.404|
|[[:human genes:f:fbxw9|FBXW9]]|0.403|
|[[:human genes:n:ndc80|NDC80]]|0.403|
|[[:human genes:p:psap|PSAP]]|0.403|
|[[:human genes:p:plk4|PLK4]]|0.402|
|[[:human genes:s:sec13|SEC13]]|0.401|
|[[:human genes:r:rnpc3|RNPC3]]|0.401|
|[[:human genes:c:cbwd6|CBWD6]]|0.401|
|[[:human genes:r:rps5|RPS5]]|0.4|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.4|
|[[:human genes:s:snip1|SNIP1]]|0.4|
|[[:human genes:t:trim52|TRIM52]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 214/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|8/28|
|bone|12/25|
|breast|17/33|
|central nervous system|13/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|1/15|
|kidney|6/21|
|liver|6/20|
|lung|18/75|
|lymphocyte|7/14|
|ovary|13/26|
|pancreas|4/24|
|peripheral nervous system|6/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 655
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAF1 Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>