======= PAPD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TENT2
  * **<color #00a2e8>Official Name</color>**: terminal nucleotidyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=167153|167153]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PIY7|Q6PIY7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAPD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAPD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614121|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAP assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to absence of light|
|dark adaptation|
|negative regulation of miRNA catabolic process|
|negative regulation of miRNA metabolic process|
|adenylyltransferase activity|
|cellular response to absence of light|
|nuclear RNA-directed RNA polymerase complex|
|5-3 RNA polymerase activity|
|cellular response to light intensity|
|regulation of miRNA catabolic process|
|polynucleotide adenylyltransferase activity|
|regulation of miRNA metabolic process|
|response to light intensity|
|histone mRNA catabolic process|
|histone mRNA metabolic process|
|RNA polyadenylation|
|RNA stabilization|
|negative regulation of RNA catabolic process|
|hippocampus development|
|hematopoietic progenitor cell differentiation|
|limbic system development|
|cellular response to light stimulus|
|retina development in camera-type eye|
|pallium development|
|cellular response to radiation|
|regulation of RNA stability|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|negative regulation of cellular catabolic process|
|telencephalon development|
|response to light stimulus|
|negative regulation of catabolic process|
|camera-type eye development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|eye development|
|visual system development|
|sensory system development|
|nucleobase-containing compound catabolic process|
|forebrain development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|response to radiation|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|sensory organ development|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|mRNA metabolic process|
|brain development|
|head development|
|regulation of cellular catabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|central nervous system development|
|regulation of catabolic process|
|neuron differentiation|
|macromolecule catabolic process|
|response to abiotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of nucleobase-containing compound metabolic process|
|ATP binding|
|generation of neurons|
|neurogenesis|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.88|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.77|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.72|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.71|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.73|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18675
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAPD4 Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>