======= PAPD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TENT4A
  * **<color #00a2e8>Official Name</color>**: terminal nucleotidyltransferase 4A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11044|11044]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5XG87|Q5XG87]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAPD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAPD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605198|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. {ECO:0000269|PubMed:23376078}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NTP transf 2|
|PAP assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SMC family protein binding|
|snoRNA polyadenylation|
|ncRNA polyadenylation|
|guanylyltransferase activity|
|negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|positive regulation of 3-UTR-mediated mRNA stabilization|
|regulation of 3-UTR-mediated mRNA stabilization|
|TRAMP complex|
|RNA 3 uridylation|
|polynucleotide adenylyltransferase activity|
|snoRNA 3-end processing|
|snoRNA processing|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|histone mRNA catabolic process|
|snoRNA metabolic process|
|mitotic chromosome condensation|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|histone mRNA metabolic process|
|RNA polyadenylation|
|chromosome condensation|
|sister chromatid cohesion|
|ncRNA 3-end processing|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|negative regulation of mRNA metabolic process|
|mitotic sister chromatid segregation|
|RNA 3-end processing|
|sister chromatid segregation|
|mitotic nuclear division|
|DNA packaging|
|regulation of mRNA stability|
|double-strand break repair|
|regulation of RNA stability|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|mRNA catabolic process|
|nuclear chromosome segregation|
|nuclear membrane|
|RNA catabolic process|
|negative regulation of cellular catabolic process|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|negative regulation of catabolic process|
|organelle fission|
|regulation of mRNA metabolic process|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ncRNA metabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|DNA repair|
|posttranscriptional regulation of gene expression|
|mitotic cell cycle process|
|mitotic cell cycle|
|mRNA metabolic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|Golgi apparatus|
|regulation of catabolic process|
|cell cycle process|
|response to drug|
|macromolecule catabolic process|
|chromosome organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of nucleobase-containing compound metabolic process|
|ATP binding|
|RNA metabolic process|
|cellular response to stress|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7941
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAPD7 Expression in NALM6 Cells: 6.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>