======= PAWR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAWR
  * **<color #00a2e8>Official Name</color>**: pro-apoptotic WT1 regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5074|5074]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96IZ0|Q96IZ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAWR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAWR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601936|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-2 biosynthetic process|
|positive regulation of amyloid precursor protein biosynthetic process|
|positive regulation of hydrogen peroxide-mediated programmed cell death|
|positive regulation of hydrogen peroxide-induced cell death|
|positive regulation of response to reactive oxygen species|
|regulation of hydrogen peroxide-mediated programmed cell death|
|interleukin-2 production|
|positive regulation of cellular response to drug|
|leucine zipper domain binding|
|regulation of amyloid precursor protein biosynthetic process|
|positive regulation of cellular senescence|
|cytokine biosynthetic process|
|positive regulation of oxidative stress-induced cell death|
|positive regulation of cell aging|
|cytokine metabolic process|
|negative regulation of B cell proliferation|
|positive regulation of cellular response to oxidative stress|
|positive regulation of response to oxidative stress|
|positive regulation of glycoprotein biosynthetic process|
|negative regulation of T cell receptor signaling pathway|
|positive regulation of glycoprotein metabolic process|
|regulation of hydrogen peroxide-induced cell death|
|negative regulation of antigen receptor-mediated signaling pathway|
|negative regulation of fibroblast proliferation|
|negative regulation of B cell activation|
|positive regulation of response to drug|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|regulation of T cell receptor signaling pathway|
|regulation of glycoprotein biosynthetic process|
|regulation of cellular senescence|
|regulation of glycoprotein metabolic process|
|regulation of cell aging|
|negative regulation of T cell proliferation|
|regulation of B cell proliferation|
|regulation of antigen receptor-mediated signaling pathway|
|actin filament bundle assembly|
|regulation of oxidative stress-induced cell death|
|actin filament bundle organization|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|regulation of cellular response to oxidative stress|
|negative regulation of leukocyte proliferation|
|actin filament|
|regulation of fibroblast proliferation|
|regulation of response to oxidative stress|
|regulation of response to drug|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of lymphocyte activation|
|cytokine production|
|regulation of T cell proliferation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|negative regulation of cell activation|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|nuclear chromatin|
|actin filament organization|
|transcription corepressor activity|
|actin binding|
|negative regulation of cell adhesion|
|apoptotic signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|enzyme binding|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|regulation of lymphocyte activation|
|actin filament-based process|
|regulation of leukocyte activation|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|positive regulation of cell death|
|regulation of cellular response to stress|
|negative regulation of transcription by RNA polymerase II|
|apoptotic process|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14662
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAWR Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>