======= PAX7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAX7
  * **<color #00a2e8>Official Name</color>**: paired box 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5081|5081]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23759|P23759]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAX7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAX7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/167410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation. {ECO:0000250|UniProtKB:P47239}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|PAX|
|Pax7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|skeletal muscle satellite cell commitment|
|skeletal muscle satellite cell differentiation|
|positive regulation of myoblast proliferation|
|regulation of myoblast proliferation|
|spinal cord association neuron differentiation|
|dorsal/ventral neural tube patterning|
|dorsal spinal cord development|
|regulation of cell fate commitment|
|neural tube patterning|
|skeletal muscle tissue regeneration|
|positive regulation of histone methylation|
|skeletal muscle cell differentiation|
|cell differentiation in spinal cord|
|tissue regeneration|
|neuron fate commitment|
|regulation of histone methylation|
|muscle tissue morphogenesis|
|dorsal/ventral pattern formation|
|muscle organ morphogenesis|
|positive regulation of histone modification|
|positive regulation of chromatin organization|
|spinal cord development|
|skeletal muscle tissue development|
|regulation of DNA binding|
|embryonic skeletal system development|
|skeletal muscle organ development|
|regulation of histone modification|
|regeneration|
|neural tube development|
|chromatin remodeling|
|cartilage development|
|positive regulation of chromosome organization|
|central nervous system neuron differentiation|
|regulation of chromatin organization|
|connective tissue development|
|cell fate commitment|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|regionalization|
|regulation of chromosome organization|
|regulation of binding|
|developmental growth|
|growth|
|sequence-specific DNA binding|
|pattern specification process|
|muscle structure development|
|wound healing|
|skeletal system development|
|tissue morphogenesis|
|response to wounding|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|DNA-binding transcription factor activity|
|chromatin organization|
|tube development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|chromosome organization|
|epithelium development|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of organelle organization|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8059
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAX7 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>