======= PBK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PBK
  * **<color #00a2e8>Official Name</color>**: PDZ binding kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55872|55872]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96KB5|Q96KB5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PBK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PBK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|cellular response to UV|
|negative regulation of cellular protein catabolic process|
|cellular response to light stimulus|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|negative regulation of inflammatory response|
|response to UV|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of MAPK cascade|
|cellular response to radiation|
|regulation of proteasomal protein catabolic process|
|negative regulation of defense response|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|response to light stimulus|
|negative regulation of catabolic process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of inflammatory response|
|negative regulation of proteolysis|
|protein serine/threonine kinase activity|
|negative regulation of response to external stimulus|
|regulation of protein catabolic process|
|negative regulation of protein phosphorylation|
|response to radiation|
|negative regulation of phosphorylation|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of cellular catabolic process|
|protein phosphorylation|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|negative regulation of signal transduction|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.7|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9970
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PBK Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>