======= PCDH8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCDH8
  * **<color #00a2e8>Official Name</color>**: protocadherin 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5100|5100]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95206|O95206]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCDH8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCDH8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603580|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
|Cadherin 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of synaptic membrane adhesion|
|integral component of postsynaptic membrane|
|somitogenesis|
|presynaptic membrane|
|somite development|
|segmentation|
|morphogenesis of embryonic epithelium|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|anterior/posterior pattern specification|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|regionalization|
|glutamatergic synapse|
|regulation of cell-cell adhesion|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|morphogenesis of an epithelium|
|pattern specification process|
|trans-synaptic signaling|
|synaptic signaling|
|cell-cell adhesion|
|cell junction|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of cell adhesion|
|calcium ion binding|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|embryo development|
|epithelium development|
|cell-cell signaling|
|integral component of plasma membrane|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.86|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.75|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6651
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCDH8 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>