======= PCSK6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCSK6
  * **<color #00a2e8>Official Name</color>**: proprotein convertase subtilisin/kexin type 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5046|5046]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29122|P29122]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCSK6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCSK6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/167405|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotrophin production|
|nerve growth factor production|
|nerve growth factor processing|
|nerve growth factor binding|
|zygotic determination of anterior/posterior axis, embryo|
|tripartite regional subdivision|
|anterior/posterior axis specification, embryo|
|blastoderm segmentation|
|regulation of lipoprotein lipase activity|
|peptide hormone processing|
|embryonic axis specification|
|anterior/posterior axis specification|
|embryonic pattern specification|
|endopeptidase activity|
|axis specification|
|regulation of BMP signaling pathway|
|segmentation|
|regulation of lipase activity|
|Golgi lumen|
|cornification|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|protein processing|
|serine-type endopeptidase activity|
|heparin binding|
|hormone metabolic process|
|anterior/posterior pattern specification|
|protein maturation|
|keratinization|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|keratinocyte differentiation|
|epidermal cell differentiation|
|regionalization|
|collagen-containing extracellular matrix|
|skin development|
|glycoprotein metabolic process|
|epidermis development|
|pattern specification process|
|peptide metabolic process|
|regulation of hormone levels|
|cell surface|
|epithelial cell differentiation|
|cellular amide metabolic process|
|embryo development|
|secretion by cell|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|export from cell|
|programmed cell death|
|cell death|
|epithelium development|
|secretion|
|proteolysis|
|regulation of hydrolase activity|
|extracellular space|
|tissue development|
|extracellular region|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13822
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCSK6 Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
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