======= PDCD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDCD4
  * **<color #00a2e8>Official Name</color>**: programmed cell death 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27250|27250]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53EL6|Q53EL6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDCD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDCD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MA3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epithelial to mesenchymal transition involved in cardiac fibroblast development|
|epicardium-derived cardiac fibroblast cell differentiation|
|negative regulation of myofibroblast differentiation|
|cardiac fibroblast cell differentiation|
|cardiac fibroblast cell development|
|epicardium-derived cardiac fibroblast cell development|
|regulation of myofibroblast differentiation|
|positive regulation of vascular associated smooth muscle cell apoptotic process|
|negative regulation of vascular smooth muscle cell differentiation|
|regulation of vascular associated smooth muscle cell apoptotic process|
|negative regulation of JUN kinase activity|
|regulation of vascular smooth muscle cell differentiation|
|positive regulation of smooth muscle cell apoptotic process|
|negative regulation of smooth muscle cell differentiation|
|negative regulation of cytokine production involved in inflammatory response|
|negative regulation of vascular smooth muscle cell proliferation|
|positive regulation of endothelial cell apoptotic process|
|regulation of smooth muscle cell apoptotic process|
|cardiac epithelial to mesenchymal transition|
|positive regulation of muscle cell apoptotic process|
|regulation of smooth muscle cell differentiation|
|positive regulation of epithelial cell apoptotic process|
|negative regulation of JNK cascade|
|regulation of cytokine production involved in inflammatory response|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of smooth muscle cell proliferation|
|negative regulation of stress-activated MAPK cascade|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|regulation of endothelial cell apoptotic process|
|regulation of vascular smooth muscle cell proliferation|
|negative regulation of muscle cell differentiation|
|cell aging|
|cardiac cell development|
|regulation of muscle cell apoptotic process|
|epithelial to mesenchymal transition|
|negative regulation of MAP kinase activity|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of epithelial cell apoptotic process|
|regulation of JUN kinase activity|
|BMP signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of vasculature development|
|cardiocyte differentiation|
|regulation of smooth muscle cell proliferation|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of inflammatory response|
|positive regulation of inflammatory response|
|regulation of muscle cell differentiation|
|mesenchymal cell differentiation|
|negative regulation of MAPK cascade|
|cellular response to lipopolysaccharide|
|regulation of JNK cascade|
|cellular response to molecule of bacterial origin|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of defense response|
|cellular response to biotic stimulus|
|mesenchyme development|
|negative regulation of protein kinase activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|heart morphogenesis|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|aging|
|response to lipopolysaccharide|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|regulation of MAP kinase activity|
|negative regulation of response to external stimulus|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|positive regulation of defense response|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|heart development|
|response to growth factor|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of transferase activity|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|negative regulation of gene expression|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.12|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.04|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.91|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.75|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12732
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDCD4 Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>