======= PDE3B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE3B
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 3B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5140|5140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13370|Q13370]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE3B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE3B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602047|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDEase I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|
|3,5-cyclic-nucleotide phosphodiesterase activity|
|negative regulation of cell adhesion mediated by integrin|
|guanyl-nucleotide exchange factor complex|
|protein kinase B binding|
|3,5-cyclic-AMP phosphodiesterase activity|
|negative regulation of lipid catabolic process|
|negative regulation of cAMP-mediated signaling|
|regulation of cell adhesion mediated by integrin|
|regulation of cAMP-mediated signaling|
|regulation of lipid catabolic process|
|negative regulation of lipid metabolic process|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|cellular response to insulin stimulus|
|response to insulin|
|cellular response to peptide hormone stimulus|
|negative regulation of cell adhesion|
|regulation of angiogenesis|
|negative regulation of catabolic process|
|angiogenesis|
|regulation of vasculature development|
|cellular response to peptide|
|response to peptide hormone|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|response to peptide|
|blood vessel development|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|tube morphogenesis|
|cellular response to nitrogen compound|
|regulation of cell adhesion|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|negative regulation of developmental process|
|Golgi apparatus|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.09|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.8|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.84|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.85|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.88|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12236
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE3B Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>