======= PDE6G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE6G
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 6G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5148|5148]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18545|P18545]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE6G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE6G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180073|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDE6 gamma|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rhodopsin mediated signaling pathway|
|cGMP binding|
|3,5-cyclic-GMP phosphodiesterase activity|
|photoreceptor outer segment membrane|
|phototransduction, visible light|
|photoreceptor disc membrane|
|regulation of rhodopsin mediated signaling pathway|
|positive regulation of G protein-coupled receptor signaling pathway|
|spectrin binding|
|enzyme inhibitor activity|
|positive regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of ERBB signaling pathway|
|Wnt signaling pathway, calcium modulating pathway|
|phototransduction|
|detection of visible light|
|detection of light stimulus|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of ERBB signaling pathway|
|cellular response to light stimulus|
|detection of external stimulus|
|detection of abiotic stimulus|
|non-canonical Wnt signaling pathway|
|regulation of G protein-coupled receptor signaling pathway|
|activation of MAPK activity|
|cellular response to radiation|
|visual perception|
|sensory perception of light stimulus|
|positive regulation of MAP kinase activity|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|response to radiation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|detection of stimulus|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|sensory perception|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.82|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.81|
|[[:results:exp303|39°C R06 exp303]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.508|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8096
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE6G Expression in NALM6 Cells: -1.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>