======= PDGFA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDGFA
  * **<color #00a2e8>Official Name</color>**: platelet derived growth factor subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5154|5154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04085|P04085]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDGFA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDGFA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDGF|
|PDGF N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic lung development|
|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|
|negative regulation of phosphatidylinositol biosynthetic process|
|regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|
|positive regulation of metanephric mesenchymal cell migration|
|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|
|regulation of metanephric mesenchymal cell migration|
|negative regulation of phospholipid biosynthetic process|
|epithelial-mesenchymal cell signaling|
|platelet-derived growth factor receptor-beta signaling pathway|
|regulation of phosphatidylinositol biosynthetic process|
|regulation of branching involved in salivary gland morphogenesis|
|negative regulation of phospholipid metabolic process|
|regulation of glomerular mesangial cell proliferation|
|platelet-derived growth factor binding|
|positive regulation of metanephros development|
|regulation of cell proliferation involved in kidney development|
|platelet-derived growth factor receptor binding|
|regulation of glomerulus development|
|regulation of phospholipid biosynthetic process|
|negative regulation of platelet activation|
|regulation of metanephros development|
|positive regulation of mesenchymal cell proliferation|
|positive regulation of protein autophosphorylation|
|regulation of platelet activation|
|platelet-derived growth factor receptor signaling pathway|
|regulation of mesenchymal cell proliferation|
|positive regulation of kidney development|
|lung alveolus development|
|negative chemotaxis|
|regulation of protein autophosphorylation|
|negative regulation of lipid biosynthetic process|
|positive regulation of fibroblast proliferation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|regulation of smooth muscle cell migration|
|microvillus|
|collagen binding|
|platelet alpha granule lumen|
|hair follicle development|
|negative regulation of wound healing|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of fibroblast proliferation|
|negative regulation of lipid metabolic process|
|regulation of coagulation|
|regulation of phospholipid metabolic process|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of response to wounding|
|positive regulation of cell division|
|hair cycle|
|molting cycle|
|Golgi lumen|
|regulation of DNA biosynthetic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|platelet degranulation|
|regulation of wound healing|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of response to wounding|
|regulation of cell division|
|lung development|
|respiratory tube development|
|regulation of morphogenesis of an epithelium|
|regulation of lipid biosynthetic process|
|respiratory system development|
|negative regulation of cell activation|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of protein kinase B signaling|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of animal organ morphogenesis|
|positive regulation of MAP kinase activity|
|regulation of ERK1 and ERK2 cascade|
|endoplasmic reticulum lumen|
|angiogenesis|
|regulation of vasculature development|
|positive regulation of protein serine/threonine kinase activity|
|extracellular matrix organization|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of DNA metabolic process|
|negative regulation of response to external stimulus|
|MAPK cascade|
|skin development|
|extracellular structure organization|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|epidermis development|
|embryonic organ development|
|cell projection assembly|
|wound healing|
|blood vessel development|
|protein heterodimerization activity|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|positive regulation of cell migration|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|response to wounding|
|positive regulation of kinase activity|
|cell surface|
|Golgi membrane|
|regulation of cell activation|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|exocytosis|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|regulation of response to external stimulus|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14047
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDGFA Expression in NALM6 Cells: 4.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>