======= PDHB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDHB
  * **<color #00a2e8>Official Name</color>**: pyruvate dehydrogenase E1 subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5162|5162]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11177|P11177]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDHB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDHB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transketolase C|
|Transket pyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyruvate dehydrogenase activity|
|pyruvate dehydrogenase (acetyl-transferring) activity|
|pyruvate dehydrogenase complex|
|mitochondrial acetyl-CoA biosynthetic process from pyruvate|
|pyruvate dehydrogenase (NAD+) activity|
|acetyl-CoA biosynthetic process from pyruvate|
|acetyl-CoA biosynthetic process|
|acetyl-CoA metabolic process|
|tricarboxylic acid cycle|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|pyruvate metabolic process|
|aerobic respiration|
|acyl-CoA metabolic process|
|thioester metabolic process|
|glucose metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|hexose metabolic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|cellular respiration|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|monosaccharide metabolic process|
|cofactor biosynthetic process|
|energy derivation by oxidation of organic compounds|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.25|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.91|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.85|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.76|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.8|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.83|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.95|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.96|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.12|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.16|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.29|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.8|
|[[:results:exp274|Citral 50μM R06 exp274]]|4.93|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|7.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pdha1|PDHA1]]|0.706|
|[[:human genes:m:mpc1|MPC1]]|0.62|
|[[:human genes:d:dlat|DLAT]]|0.577|
|[[:human genes:m:mdh1|MDH1]]|0.533|
|[[:human genes:p:pdhx|PDHX]]|0.533|
|[[:human genes:m:mpc2|MPC2]]|0.449|
|[[:human genes:c:cs|CS]]|0.442|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.437|
|[[:human genes:p:pdp2|PDP2]]|0.422|
|[[:human genes:p:pdp1|PDP1]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11353
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDHB Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>