======= PDX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDX1
  * **<color #00a2e8>Official Name</color>**: pancreatic and duodenal homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3651|3651]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52945|P52945]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to chlorate|
|detection of monosaccharide stimulus|
|detection of glucose|
|detection of hexose stimulus|
|detection of carbohydrate stimulus|
|animal organ senescence|
|response to iron(II) ion|
|negative regulation of type B pancreatic cell apoptotic process|
|transdifferentiation|
|exocrine pancreas development|
|regulation of type B pancreatic cell apoptotic process|
|response to leucine|
|type B pancreatic cell differentiation|
|nitric oxide mediated signal transduction|
|enteroendocrine cell differentiation|
|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|response to iron ion|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|glandular epithelial cell differentiation|
|endocrine pancreas development|
|insulin secretion|
|negative regulation of epithelial cell apoptotic process|
|exocrine system development|
|negative regulation of response to endoplasmic reticulum stress|
|response to nicotine|
|promoter-specific chromatin binding|
|positive regulation of DNA binding|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|peptide hormone secretion|
|positive regulation of insulin secretion|
|smoothened signaling pathway|
|pancreas development|
|hormone secretion|
|animal organ regeneration|
|regulation of epithelial cell apoptotic process|
|hormone transport|
|regulation of response to endoplasmic reticulum stress|
|response to fatty acid|
|response to vitamin|
|negative regulation of intrinsic apoptotic signaling pathway|
|columnar/cuboidal epithelial cell differentiation|
|positive regulation of peptide hormone secretion|
|response to alkaloid|
|glucose metabolic process|
|response to amino acid|
|endocrine system development|
|liver development|
|regulation of DNA binding|
|positive regulation of hormone secretion|
|hepaticobiliary system development|
|digestive tract development|
|response to glucose|
|response to hexose|
|digestive system development|
|morphogenesis of embryonic epithelium|
|response to glucocorticoid|
|response to monosaccharide|
|regeneration|
|hexose metabolic process|
|protein secretion|
|stem cell differentiation|
|establishment of protein localization to extracellular region|
|regulation of intrinsic apoptotic signaling pathway|
|response to corticosteroid|
|protein localization to extracellular region|
|signal release|
|response to carbohydrate|
|peptide secretion|
|positive regulation of binding|
|regulation of insulin secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|monosaccharide metabolic process|
|regulation of peptide hormone secretion|
|response to nutrient|
|negative regulation of apoptotic signaling pathway|
|protein-containing complex binding|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|aging|
|positive regulation of peptide secretion|
|response to steroid hormone|
|transcription factor binding|
|second-messenger-mediated signaling|
|response to acid chemical|
|response to metal ion|
|regulation of binding|
|regulation of apoptotic signaling pathway|
|nuclear speck|
|positive regulation of secretion by cell|
|gland development|
|generation of precursor metabolites and energy|
|positive regulation of protein transport|
|morphogenesis of an epithelium|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|carbohydrate metabolic process|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|regulation of peptide secretion|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|detection of chemical stimulus|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of hormone levels|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|detection of stimulus|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|regulation of protein localization|
|export from cell|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11778
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDX1 Expression in NALM6 Cells: 1.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>