======= PEX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEX3
  * **<color #00a2e8>Official Name</color>**: peroxisomal biogenesis factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8504|8504]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56589|P56589]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603164|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes. {ECO:0000269|PubMed:10848631, ECO:0000269|PubMed:15007061}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peroxin-3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-lipid complex|
|peroxisome membrane biogenesis|
|protein import into peroxisome membrane|
|integral component of peroxisomal membrane|
|peroxisomal membrane transport|
|membrane biogenesis|
|peroxisomal membrane|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|protein binding, bridging|
|peroxisome organization|
|peroxisome|
|protein import|
|lipid binding|
|protein dimerization activity|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein-containing complex|
|protein localization to organelle|
|intracellular protein transport|
|endoplasmic reticulum|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.13|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.91|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.88|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.82|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.72|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.13|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.94|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|3.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pex1|PEX1]]|0.511|
|[[:human genes:p:pex12|PEX12]]|0.493|
|[[:human genes:p:pex13|PEX13]]|0.452|
|[[:human genes:p:pex2|PEX2]]|0.446|
|[[:human genes:a:abcd3|ABCD3]]|0.443|
|[[:human genes:l:ldlrap1|LDLRAP1]]|0.41|
|[[:human genes:p:pex10|PEX10]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13286
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEX3 Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>