======= PFDN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PFDN2
  * **<color #00a2e8>Official Name</color>**: prefoldin subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5202|5202]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHV9|Q9UHV9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PFDN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PFDN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613466|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prefoldin 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prefoldin complex|
|protein folding chaperone|
|unfolded protein binding|
|positive regulation of cytoskeleton organization|
|protein folding|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.12|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.9|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.86|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.84|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.81|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.78|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2110
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PFDN2 Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>