======= PFKFB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PFKFB1
  * **<color #00a2e8>Official Name</color>**: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5207|5207]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16118|P16118]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PFKFB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PFKFB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/311790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Synthesis and degradation of fructose 2,6-bisphosphate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|6PF2K|
|His Phos 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex|
|6-phosphofructo-2-kinase activity|
|fructose 2,6-bisphosphate metabolic process|
|fructose-6-phosphate binding|
|positive regulation of glucokinase activity|
|fructose-2,6-bisphosphate 2-phosphatase activity|
|positive regulation of hexokinase activity|
|regulation of glucokinase activity|
|regulation of hexokinase activity|
|negative regulation of glycolytic process|
|fructose metabolic process|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|positive regulation of glycolytic process|
|carbohydrate phosphorylation|
|negative regulation of ATP metabolic process|
|response to glucagon|
|glycolytic process|
|ATP generation from ADP|
|negative regulation of cellular carbohydrate metabolic process|
|gluconeogenesis|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|hexose biosynthetic process|
|negative regulation of carbohydrate metabolic process|
|ADP metabolic process|
|monosaccharide biosynthetic process|
|positive regulation of cellular carbohydrate metabolic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine nucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|animal organ regeneration|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|nucleoside diphosphate metabolic process|
|regulation of carbohydrate catabolic process|
|negative regulation of small molecule metabolic process|
|kinase binding|
|response to cAMP|
|glucose metabolic process|
|regulation of glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|carbohydrate catabolic process|
|regulation of ATP metabolic process|
|carbohydrate biosynthetic process|
|response to organophosphorus|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|response to glucocorticoid|
|response to purine-containing compound|
|hexose metabolic process|
|regeneration|
|regulation of generation of precursor metabolites and energy|
|response to corticosteroid|
|cellular carbohydrate metabolic process|
|response to starvation|
|monosaccharide metabolic process|
|ATP metabolic process|
|regulation of carbohydrate metabolic process|
|response to insulin|
|dephosphorylation|
|negative regulation of catabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|response to steroid hormone|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|positive regulation of cellular catabolic process|
|purine-containing compound metabolic process|
|response to peptide hormone|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to peptide|
|carbohydrate metabolic process|
|response to nutrient levels|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|nucleobase-containing small molecule metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|small molecule biosynthetic process|
|positive regulation of transferase activity|
|regulation of cellular catabolic process|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|regulation of transferase activity|
|regulation of catabolic process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|phosphorylation|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18742
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PFKFB1 Expression in NALM6 Cells: -0.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>