======= PGM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGM1
  * **<color #00a2e8>Official Name</color>**: phosphoglucomutase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5236|5236]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36871|P36871]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/171900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PGM PMM I|
|PGM PMM II|
|PGM PMM IV|
|PGM PMM III|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoglucomutase activity|
|galactose catabolic process|
|galactose metabolic process|
|glycogen catabolic process|
|glucan catabolic process|
|glucan biosynthetic process|
|glycogen biosynthetic process|
|cellular polysaccharide catabolic process|
|polysaccharide catabolic process|
|cellular carbohydrate catabolic process|
|glycolytic process|
|ATP generation from ADP|
|polysaccharide biosynthetic process|
|gluconeogenesis|
|cellular polysaccharide biosynthetic process|
|hexose biosynthetic process|
|glycogen metabolic process|
|glucan metabolic process|
|ADP metabolic process|
|cellular glucan metabolic process|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|tertiary granule lumen|
|cellular carbohydrate biosynthetic process|
|nucleoside diphosphate phosphorylation|
|monosaccharide catabolic process|
|purine nucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|energy reserve metabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|nucleoside diphosphate metabolic process|
|glucose metabolic process|
|carbohydrate catabolic process|
|ficolin-1-rich granule lumen|
|carbohydrate biosynthetic process|
|hexose metabolic process|
|cellular carbohydrate metabolic process|
|monosaccharide metabolic process|
|ATP metabolic process|
|magnesium ion binding|
|actin cytoskeleton|
|energy derivation by oxidation of organic compounds|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|leukocyte activation|
|oxidation-reduction process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|export from cell|
|macromolecule catabolic process|
|cell activation|
|immune effector process|
|secretion|
|phosphorylation|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.76|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15998
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGM1 Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>