======= PHACTR4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHACTR4
  * **<color #00a2e8>Official Name</color>**: phosphatase and actin regulator 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65979|65979]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZ21|Q8IZ21]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHACTR4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHACTR4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608726|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RPEL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of integrin-mediated signaling pathway|
|closure of optic fissure|
|optic cup morphogenesis involved in camera-type eye development|
|protein phosphatase activator activity|
|embryonic camera-type eye formation|
|enteric nervous system development|
|regulation of integrin-mediated signaling pathway|
|protein phosphatase 1 binding|
|embryonic camera-type eye morphogenesis|
|embryonic eye morphogenesis|
|embryonic camera-type eye development|
|autonomic nervous system development|
|morphogenesis of an epithelial sheet|
|neural crest cell migration|
|Rho protein signal transduction|
|neural crest cell development|
|stem cell development|
|mesenchymal cell development|
|neural crest cell differentiation|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|neural tube formation|
|camera-type eye morphogenesis|
|regulation of phosphoprotein phosphatase activity|
|embryonic epithelial tube formation|
|epithelial tube formation|
|regulation of protein dephosphorylation|
|morphogenesis of embryonic epithelium|
|eye morphogenesis|
|tube formation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|neural tube development|
|ameboidal-type cell migration|
|regulation of phosphatase activity|
|lamellipodium|
|regulation of dephosphorylation|
|mesenchyme development|
|Ras protein signal transduction|
|sensory organ morphogenesis|
|actin binding|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|camera-type eye development|
|small GTPase mediated signal transduction|
|eye development|
|visual system development|
|sensory system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|actin cytoskeleton organization|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|regulation of cell cycle|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|cell development|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.7|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.44|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.26|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.01|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.95|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.93|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.93|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.89|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.88|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.74|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.77|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.8|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.9|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11979
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHACTR4 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>