======= PI4KB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PI4KB
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol 4-kinase beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5298|5298]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBF8|Q9UBF8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PI4KB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PI4KB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602758|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3 PI4 kinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-phosphatidylinositol 4-kinase activity|
|rough endoplasmic reticulum membrane|
|14-3-3 protein binding|
|phosphatidylinositol phosphorylation|
|lipid phosphorylation|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|phosphatidylinositol biosynthetic process|
|mitochondrial outer membrane|
|phosphatidylinositol metabolic process|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|receptor-mediated endocytosis|
|phospholipid biosynthetic process|
|endosome|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organophosphate biosynthetic process|
|endocytosis|
|lipid biosynthetic process|
|Golgi membrane|
|import into cell|
|perinuclear region of cytoplasm|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|phosphorylation|
|ATP binding|
|intracellular signal transduction|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.41|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.74|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.71|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.68|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.47|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.35|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.32|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.26|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.24|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.23|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.03|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.94|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.88|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.81|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.79|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.79|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.7|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.7|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.72|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.78|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.9|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.91|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.92|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.94|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.07|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.26|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.68|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cog4|COG4]]|0.491|
|[[:human genes:c:c10orf76|C10orf76]]|0.482|
|[[:human genes:p:prim1|PRIM1]]|0.456|
|[[:human genes:p:polr2j3|POLR2J3]]|0.444|
|[[:human genes:s:sptlc2|SPTLC2]]|0.435|
|[[:human genes:c:cog7|COG7]]|0.43|
|[[:human genes:g:gpr107|GPR107]]|0.426|
|[[:human genes:w:wdr7|WDR7]]|0.417|
|[[:human genes:c:cog1|COG1]]|0.417|
|[[:human genes:z:zfat|ZFAT]]|0.417|
|[[:human genes:v:vps54|VPS54]]|0.415|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.413|
|[[:human genes:w:wapal|WAPAL]]|0.41|
|[[:human genes:c:col4a3bp|COL4A3BP]]|0.406|
|[[:human genes:m:myb|MYB]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1601
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PI4KB Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>