======= PIAS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIAS1
  * **<color #00a2e8>Official Name</color>**: protein inhibitor of activated STAT 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8554|8554]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75925|O75925]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIAS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIAS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603566|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:19136629, ECO:0000269|PubMed:21965678}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-MIZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SUMO ligase activity|
|positive regulation of protein sumoylation|
|positive regulation of smooth muscle cell differentiation|
|SUMO transferase activity|
|regulation of protein sumoylation|
|regulation of interferon-gamma-mediated signaling pathway|
|regulation of response to interferon-gamma|
|regulation of smooth muscle cell differentiation|
|androgen receptor signaling pathway|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|androgen receptor binding|
|visual learning|
|visual behavior|
|RNA polymerase II transcription factor binding|
|protein sumoylation|
|intracellular steroid hormone receptor signaling pathway|
|associative learning|
|transcription coregulator activity|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of muscle cell differentiation|
|positive regulation of ubiquitin-dependent protein catabolic process|
|PML body|
|positive regulation of proteasomal protein catabolic process|
|fat cell differentiation|
|steroid hormone mediated signaling pathway|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|learning|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of muscle cell differentiation|
|intracellular receptor signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|hormone-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of proteasomal protein catabolic process|
|cellular response to steroid hormone stimulus|
|protein C-terminus binding|
|protein-DNA complex assembly|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|transcription corepressor activity|
|protein-DNA complex subunit organization|
|protein domain specific binding|
|regulation of cellular protein catabolic process|
|learning or memory|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|transcription coactivator activity|
|ubiquitin protein ligase binding|
|cognition|
|response to light stimulus|
|peptidyl-lysine modification|
|response to steroid hormone|
|enzyme binding|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|nuclear speck|
|positive regulation of catabolic process|
|response to radiation|
|regulation of innate immune response|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|cellular response to organic cyclic compound|
|spermatogenesis|
|male gamete generation|
|behavior|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|mitotic cell cycle|
|gamete generation|
|regulation of proteolysis|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|zinc ion binding|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|cell cycle process|
|regulation of response to external stimulus|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.2|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.78|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.76|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.76|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.75|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.79|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.8|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.87|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.94|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.95|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.03|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4691
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIAS1 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>