======= PIAS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIAS3
  * **<color #00a2e8>Official Name</color>**: protein inhibitor of activated STAT 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10401|10401]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6X2|Q9Y6X2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIAS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIAS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605987|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:9388184}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-MIZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TNFSF11-mediated signaling pathway|
|SUMO ligase activity|
|negative regulation of protein sumoylation|
|positive regulation of protein sumoylation|
|positive regulation of membrane potential|
|SUMO transferase activity|
|regulation of protein sumoylation|
|negative regulation of osteoclast differentiation|
|potassium channel regulator activity|
|negative regulation of myeloid leukocyte differentiation|
|RNA polymerase II transcription factor binding|
|regulation of osteoclast differentiation|
|protein sumoylation|
|negative regulation of myeloid cell differentiation|
|transcription coregulator activity|
|negative regulation of protein modification by small protein conjugation or removal|
|negative regulation of leukocyte differentiation|
|protein N-terminus binding|
|regulation of myeloid leukocyte differentiation|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of protein modification by small protein conjugation or removal|
|negative regulation of hemopoiesis|
|protein C-terminus binding|
|regulation of myeloid cell differentiation|
|regulation of protein modification by small protein conjugation or removal|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|synapse|
|regulation of leukocyte differentiation|
|peptidyl-lysine modification|
|enzyme binding|
|nuclear speck|
|dendrite|
|regulation of membrane potential|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|negative regulation of protein modification process|
|cytokine-mediated signaling pathway|
|negative regulation of cell differentiation|
|protein modification by small protein conjugation|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|response to hormone|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3907
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIAS3 Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>