======= PIBF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIBF1
  * **<color #00a2e8>Official Name</color>**: progesterone immunomodulatory binding factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10464|10464]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WXW3|Q8WXW3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIBF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIBF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607532|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of prostaglandin biosynthetic process|
|interleukin-4 receptor binding|
|activation of Janus kinase activity|
|negative regulation of natural killer cell activation|
|regulation of prostaglandin biosynthetic process|
|regulation of unsaturated fatty acid biosynthetic process|
|negative regulation of tyrosine phosphorylation of STAT protein|
|negative regulation of fatty acid biosynthetic process|
|negative regulation of interleukin-12 production|
|negative regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of receptor signaling pathway via STAT|
|protein localization to centrosome|
|protein localization to microtubule organizing center|
|negative regulation of fatty acid metabolic process|
|centriolar satellite|
|regulation of natural killer cell activation|
|protein localization to microtubule cytoskeleton|
|positive regulation of interleukin-10 production|
|mitotic spindle assembly|
|protein localization to cytoskeleton|
|non-motile cilium assembly|
|regulation of fatty acid biosynthetic process|
|mitotic metaphase plate congression|
|negative regulation of lipid biosynthetic process|
|negative regulation of peptidyl-tyrosine phosphorylation|
|regulation of interleukin-10 production|
|regulation of interleukin-12 production|
|metaphase plate congression|
|positive regulation of tyrosine phosphorylation of STAT protein|
|establishment of chromosome localization|
|chromosome localization|
|mitotic spindle organization|
|regulation of tyrosine phosphorylation of STAT protein|
|negative regulation of lipid metabolic process|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of fatty acid metabolic process|
|positive regulation of receptor signaling pathway via STAT|
|negative regulation of small molecule metabolic process|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|sister chromatid segregation|
|peptidyl-tyrosine phosphorylation|
|negative regulation of lymphocyte activation|
|mitotic nuclear division|
|peptidyl-tyrosine modification|
|spindle organization|
|microtubule organizing center|
|regulation of cellular ketone metabolic process|
|negative regulation of leukocyte activation|
|regulation of lipid biosynthetic process|
|positive regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell activation|
|nuclear chromosome segregation|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cytokine production|
|chromosome segregation|
|nuclear division|
|organelle fission|
|activation of protein kinase activity|
|cilium assembly|
|establishment of organelle localization|
|cilium organization|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|positive regulation of cytokine production|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|regulation of lymphocyte activation|
|positive regulation of protein kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of leukocyte activation|
|regulation of cell activation|
|positive regulation of transferase activity|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cytokine production|
|protein localization to organelle|
|organelle assembly|
|regulation of protein kinase activity|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|chromosome organization|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.72|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.7|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.71|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.8|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.8|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.86|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.99|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.84|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|6.43|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|6.48|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|7.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:casp2|CASP2]]|0.71|
|[[:human genes:c:c2cd3|C2CD3]]|0.689|
|[[:human genes:o:odf2|ODF2]]|0.672|
|[[:human genes:c:cradd|CRADD]]|0.668|
|[[:human genes:c:ccdc41|CCDC41]]|0.661|
|[[:human genes:p:pidd|PIDD]]|0.653|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.646|
|[[:human genes:c:cep76|CEP76]]|0.622|
|[[:human genes:o:ofd1|OFD1]]|0.621|
|[[:human genes:c:c14orf80|C14orf80]]|0.599|
|[[:human genes:s:sclt1|SCLT1]]|0.598|
|[[:human genes:n:nin|NIN]]|0.576|
|[[:human genes:c:c16orf59|C16orf59]]|0.572|
|[[:human genes:a:ankrd26|ANKRD26]]|0.572|
|[[:human genes:c:cep120|CEP120]]|0.57|
|[[:human genes:t:tubd1|TUBD1]]|0.568|
|[[:human genes:f:fopnl|FOPNL]]|0.561|
|[[:human genes:c:cep128|CEP128]]|0.53|
|[[:human genes:c:cep78|CEP78]]|0.503|
|[[:human genes:t:tube1|TUBE1]]|0.487|
|[[:human genes:h:hyls1|HYLS1]]|0.45|
|[[:human genes:c:cep44|CEP44]]|0.434|
|[[:human genes:r:rttn|RTTN]]|0.434|
|[[:human genes:k:kiaa0586|KIAA0586]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17975
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIBF1 Expression in NALM6 Cells: 4.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>