======= PIK3C2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3C2A
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5286|5286]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00443|O00443]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3C2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3C2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603601|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin- mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin- independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:9337861}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3 PI4 kinase|
|PI3K C2|
|PI3K rbd|
|PX|
|C2|
|PI3Ka|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 3-kinase activity|
|1-phosphatidylinositol-4-phosphate 3-kinase activity|
|1-phosphatidylinositol-3-kinase activity|
|phosphatidylinositol-3-phosphate biosynthetic process|
|vascular smooth muscle contraction|
|clathrin coat assembly|
|phosphatidylinositol 3-kinase complex|
|positive regulation of cell migration involved in sprouting angiogenesis|
|vasoconstriction|
|platelet-derived growth factor receptor signaling pathway|
|phosphatidylinositol 3-kinase signaling|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of blood vessel diameter|
|positive regulation of sprouting angiogenesis|
|epidermal growth factor receptor signaling pathway|
|phosphatidylinositol phosphorylation|
|smooth muscle contraction|
|positive regulation of blood vessel endothelial cell migration|
|clathrin-coated vesicle|
|lipid phosphorylation|
|regulation of sprouting angiogenesis|
|ERBB signaling pathway|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|phosphatidylinositol binding|
|insulin receptor signaling pathway|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell migration|
|phosphatidylinositol biosynthetic process|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|positive regulation of epithelial cell migration|
|vesicle|
|regulation of endothelial cell migration|
|cellular response to insulin stimulus|
|positive regulation of angiogenesis|
|phosphatidylinositol metabolic process|
|vascular process in circulatory system|
|positive regulation of vasculature development|
|lipid modification|
|glycerophospholipid biosynthetic process|
|regulation of epithelial cell migration|
|glycerolipid biosynthetic process|
|response to insulin|
|phospholipid biosynthetic process|
|muscle contraction|
|cellular response to peptide hormone stimulus|
|regulation of angiogenesis|
|muscle system process|
|glycerophospholipid metabolic process|
|regulation of vasculature development|
|cellular response to peptide|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|response to peptide|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|endocytosis|
|lipid biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|import into cell|
|enzyme linked receptor protein signaling pathway|
|exocytosis|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|membrane organization|
|organophosphate metabolic process|
|response to hormone|
|regulation of cell motility|
|cellular lipid metabolic process|
|cell migration|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|secretion|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|response to endogenous stimulus|
|ATP binding|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.81|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.8|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17488
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3C2A Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>