======= PIK3C3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3C3
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol 3-kinase catalytic subunit type 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5289|5289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NEB9|Q8NEB9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3C3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3C3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602609|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:7628435, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3Ka|
|PI3K C2|
|PI3 PI4 kinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 3-kinase complex, class III, type II|
|phosphatidylinositol 3-kinase complex, class III, type I|
|phosphatidylinositol 3-kinase complex, class III|
|autophagy of peroxisome|
|autolysosome|
|1-phosphatidylinositol-3-kinase activity|
|protein localization to phagophore assembly site|
|response to leucine|
|phosphatidylinositol-3-phosphate biosynthetic process|
|toll-like receptor 9 signaling pathway|
|early endosome to late endosome transport|
|vesicle-mediated transport between endosomal compartments|
|phagophore assembly site|
|cellular response to glucose starvation|
|phosphatidylinositol phosphorylation|
|autophagosome assembly|
|autophagosome organization|
|lipid phosphorylation|
|phosphatidylinositol-mediated signaling|
|phagocytic vesicle membrane|
|inositol lipid-mediated signaling|
|endosome organization|
|kinase activity|
|protein lipidation|
|regulation of cytokinesis|
|lipoprotein biosynthetic process|
|toll-like receptor signaling pathway|
|axoneme|
|peroxisome|
|phosphatidylinositol biosynthetic process|
|response to amino acid|
|lipoprotein metabolic process|
|late endosome|
|pattern recognition receptor signaling pathway|
|vacuole organization|
|cytosolic transport|
|cellular response to starvation|
|midbody|
|protein processing|
|macroautophagy|
|phosphatidylinositol metabolic process|
|regulation of cell division|
|response to starvation|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|protein maturation|
|cellular response to nutrient levels|
|innate immune response-activating signal transduction|
|protein kinase activity|
|phospholipid biosynthetic process|
|activation of innate immune response|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|endosome|
|vesicle organization|
|glycerophospholipid metabolic process|
|cellular response to external stimulus|
|positive regulation of innate immune response|
|response to acid chemical|
|positive regulation of response to biotic stimulus|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|endomembrane system organization|
|regulation of innate immune response|
|regulation of protein secretion|
|positive regulation of defense response|
|cell division|
|regulation of peptide secretion|
|response to nutrient levels|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|endocytosis|
|immune response-activating signal transduction|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|import into cell|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|organelle assembly|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of secretion|
|positive regulation of immune response|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|protein phosphorylation|
|response to organonitrogen compound|
|regulation of protein localization|
|response to nitrogen compound|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of cell cycle|
|lipid metabolic process|
|proteolysis|
|phosphorylation|
|cell cycle|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|ATP binding|
|intracellular transport|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.37|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.96|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.95|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.92|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.89|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.84|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.82|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.78|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.74|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kdsr|KDSR]]|0.449|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.437|
|[[:human genes:d:ddx42|DDX42]]|0.429|
|[[:human genes:v:vps45|VPS45]]|0.42|
|[[:human genes:m:mbtps1|MBTPS1]]|0.416|
|[[:human genes:s:sec62|SEC62]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 367/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|3/28|
|bone|12/26|
|breast|20/33|
|central nervous system|20/56|
|cervix|3/4|
|colorectal|9/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|13/21|
|liver|12/20|
|lung|41/75|
|lymphocyte|6/16|
|ovary|15/26|
|pancreas|14/24|
|peripheral nervous system|8/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|14/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 365
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3C3 Expression in NALM6 Cells: 5.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>