======= PIK3CB =======
== Gene Information ==
* **Official Symbol**: PIK3CB
* **Official Name**: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5291|5291]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P42338|P42338]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=PIK3CB&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3CB|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/602925|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: N/A
* **UniProt Summary**: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. {ECO:0000269|PubMed:18594509, ECO:0000269|PubMed:18755892, ECO:0000269|PubMed:21030680, ECO:0000269|PubMed:21383062}.
|PI3K p85B|
|PI3K rbd|
|PI3 PI4 kinase|
|PI3K C2|
|PI3Ka|
|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|
|positive regulation of neutrophil apoptotic process|
|phosphatidylinositol 3-kinase activity|
|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|
|regulation of neutrophil apoptotic process|
|1-phosphatidylinositol-4-phosphate 3-kinase activity|
|embryonic cleavage|
|positive regulation of myeloid cell apoptotic process|
|1-phosphatidylinositol-3-kinase activity|
|insulin receptor substrate binding|
|phosphatidylinositol-3-phosphate biosynthetic process|
|angiogenesis involved in wound healing|
|regulation of clathrin-dependent endocytosis|
|phosphatidylinositol 3-kinase complex|
|endothelial cell proliferation|
|positive regulation of leukocyte apoptotic process|
|regulation of myeloid cell apoptotic process|
|phosphatidylinositol 3-kinase signaling|
|platelet aggregation|
|phosphatidylinositol phosphorylation|
|homotypic cell-cell adhesion|
|lipid phosphorylation|
|vascular endothelial growth factor receptor signaling pathway|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|kinase activity|
|regulation of leukocyte apoptotic process|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|epithelial cell proliferation|
|regulation of receptor-mediated endocytosis|
|phosphatidylinositol biosynthetic process|
|regulation of cell-matrix adhesion|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of autophagy|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|platelet activation|
|Fc-gamma receptor signaling pathway|
|activation of MAPK activity|
|midbody|
|positive regulation of protein kinase B signaling|
|phosphatidylinositol metabolic process|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|Fc-epsilon receptor signaling pathway|
|T cell receptor signaling pathway|
|lipid modification|
|regulation of endocytosis|
|glycerophospholipid biosynthetic process|
|regulation of cell-substrate adhesion|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|Fc receptor signaling pathway|
|phospholipid biosynthetic process|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|process utilizing autophagic mechanism|
|autophagy|
|neuron projection guidance|
|positive regulation of MAP kinase activity|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|hemostasis|
|glycerophospholipid metabolic process|
|angiogenesis|
|activation of protein kinase activity|
|phagocytosis|
|regulation of autophagy|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of cellular catabolic process|
|axonogenesis|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|leukocyte migration|
|blood vessel morphogenesis|
|axon development|
|positive regulation of catabolic process|
|cell morphogenesis involved in neuron differentiation|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|cell division|
|regulation of body fluid levels|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|cell population proliferation|
|endocytosis|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|response to wounding|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|tube morphogenesis|
|positive regulation of transferase activity|
|neuron projection development|
|cytokine-mediated signaling pathway|
|import into cell|
|regulation of cell adhesion|
|positive regulation of cell death|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cell morphogenesis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|tube development|
|nucleolus|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|cell migration|
|embryo development|
|regulation of transferase activity|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.78|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 12440
* **Expression level (log2 read counts)**: 4.96
{{:chemogenomics:nalm6 dist.png?nolink |}}