======= PIK3CG =======
== Gene Information ==
* **Official Symbol**: PIK3CG
* **Official Name**: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5294|5294]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P48736|P48736]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=PIK3CG&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3CG|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/601232|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015].
* **UniProt Summary**: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin- based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B- lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:12163475, ECO:0000269|PubMed:15294162, ECO:0000269|PubMed:16094730, ECO:0000269|PubMed:21393242, ECO:0000269|PubMed:7624799}.
|PI3 PI4 kinase|
|PI3K C2|
|PI3K rbd|
|PI3Ka|
|natural killer cell chemotaxis|
|phosphatidylinositol 3-kinase complex, class IB|
|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|
|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|
|phosphatidylinositol 3-kinase activity|
|negative regulation of triglyceride catabolic process|
|neutrophil extravasation|
|negative regulation of cardiac muscle contraction|
|negative regulation of fibroblast apoptotic process|
|1-phosphatidylinositol-4-phosphate 3-kinase activity|
|respiratory burst involved in defense response|
|negative regulation of striated muscle contraction|
|negative regulation of triglyceride metabolic process|
|secretory granule localization|
|1-phosphatidylinositol-3-kinase activity|
|hepatocyte apoptotic process|
|regulation of triglyceride catabolic process|
|T cell chemotaxis|
|phosphatidylinositol-3-phosphate biosynthetic process|
|regulation of fibroblast apoptotic process|
|mast cell activation involved in immune response|
|mast cell degranulation|
|dendritic cell chemotaxis|
|mast cell mediated immunity|
|phosphatidylinositol 3-kinase complex|
|respiratory burst|
|dendritic cell migration|
|mast cell granule|
|negative regulation of lipid catabolic process|
|negative regulation of muscle contraction|
|mast cell activation|
|negative regulation of heart contraction|
|epithelial cell apoptotic process|
|T cell migration|
|ephrin receptor binding|
|positive regulation of acute inflammatory response|
|negative regulation of blood circulation|
|phosphatidylinositol 3-kinase signaling|
|regulation of triglyceride metabolic process|
|T cell proliferation|
|cellular extravasation|
|regulation of acute inflammatory response|
|platelet aggregation|
|lysosome localization|
|regulation of cell adhesion mediated by integrin|
|lymphocyte chemotaxis|
|phosphatidylinositol phosphorylation|
|cellular response to cAMP|
|regulation of lipid catabolic process|
|homotypic cell-cell adhesion|
|lipid phosphorylation|
|lymphocyte migration|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|regulation of cardiac muscle contraction|
|kinase activity|
|neutrophil chemotaxis|
|negative regulation of lipid metabolic process|
|lymphocyte proliferation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|mononuclear cell proliferation|
|granulocyte chemotaxis|
|regulation of striated muscle contraction|
|neutrophil migration|
|leukocyte proliferation|
|response to cAMP|
|granulocyte migration|
|phosphatidylinositol biosynthetic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|myeloid leukocyte migration|
|response to organophosphorus|
|platelet activation|
|positive regulation of inflammatory response|
|leukocyte chemotaxis|
|regulation of calcium ion transmembrane transport|
|cytokine production|
|response to purine-containing compound|
|regulation of muscle contraction|
|positive regulation of protein kinase B signaling|
|phosphatidylinositol metabolic process|
|vesicle localization|
|lipid modification|
|glycerophospholipid biosynthetic process|
|cell chemotaxis|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|regulation of muscle system process|
|T cell activation|
|protein kinase activity|
|regulation of heart contraction|
|phospholipid biosynthetic process|
|regulation of calcium ion transport|
|negative regulation of cellular catabolic process|
|positive regulation of MAP kinase activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|blood coagulation|
|coagulation|
|hemostasis|
|glycerophospholipid metabolic process|
|negative regulation of catabolic process|
|angiogenesis|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|establishment of organelle localization|
|protein serine/threonine kinase activity|
|phospholipid metabolic process|
|leukocyte migration|
|glycerolipid metabolic process|
|lymphocyte activation|
|regulation of metal ion transport|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|wound healing|
|blood vessel development|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|inflammatory response|
|cell-cell adhesion|
|leukocyte degranulation|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|cardiovascular system development|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cell population proliferation|
|endocytosis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|response to wounding|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|organelle localization|
|myeloid leukocyte activation|
|regulation of system process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|adaptive immune response|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|tube morphogenesis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|import into cell|
|regulation of cell adhesion|
|regulation of ion transport|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cellular lipid metabolic process|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|chemical homeostasis|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|intracellular transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.74|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.82|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.52|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 5355
* **Expression level (log2 read counts)**: 6.05
{{:chemogenomics:nalm6 dist.png?nolink |}}