======= PIK3R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3R1
  * **<color #00a2e8>Official Name</color>**: phosphoinositide-3-kinase regulatory subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5295|5295]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27986|P27986]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/171833|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGAP|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 3-kinase complex, class IA|
|ErbB-3 class receptor binding|
|phosphatidylinositol 3-kinase regulator activity|
|perinuclear endoplasmic reticulum membrane|
|insulin binding|
|neurotrophin TRKA receptor binding|
|phosphatidylinositol 3-kinase regulatory subunit binding|
|insulin receptor substrate binding|
|positive regulation of endoplasmic reticulum unfolded protein response|
|transmembrane receptor protein tyrosine kinase adaptor activity|
|insulin-like growth factor receptor signaling pathway|
|1-phosphatidylinositol-3-kinase regulator activity|
|insulin-like growth factor receptor binding|
|growth hormone receptor signaling pathway|
|phosphatidylinositol 3-kinase complex|
|cellular response to growth hormone stimulus|
|phosphatidylinositol 3-kinase binding|
|insulin receptor binding|
|regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of osteoclast differentiation|
|ERBB2 signaling pathway|
|phosphatidylinositol 3-kinase signaling|
|extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of RNA splicing|
|response to growth hormone|
|positive regulation of response to endoplasmic reticulum stress|
|positive regulation of protein import into nucleus|
|positive regulation of glucose import|
|negative regulation of cell-matrix adhesion|
|positive regulation of protein import|
|phosphotyrosine residue binding|
|positive regulation of glucose transmembrane transport|
|negative regulation of myeloid leukocyte differentiation|
|epidermal growth factor receptor signaling pathway|
|phosphatidylinositol phosphorylation|
|regulation of phosphatidylinositol 3-kinase activity|
|T cell costimulation|
|regulation of glucose import|
|positive regulation of protein localization to plasma membrane|
|lymphocyte costimulation|
|regulation of protein import into nucleus|
|regulation of protein import|
|positive regulation of protein localization to cell periphery|
|regulation of lipid kinase activity|
|negative regulation of cell-substrate adhesion|
|positive regulation of nucleocytoplasmic transport|
|regulation of insulin receptor signaling pathway|
|cis-Golgi network|
|regulation of osteoclast differentiation|
|lipid phosphorylation|
|vascular endothelial growth factor receptor signaling pathway|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|ERBB signaling pathway|
|phosphatidylinositol-mediated signaling|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|positive regulation of protein localization to nucleus|
|inositol lipid-mediated signaling|
|negative regulation of myeloid cell differentiation|
|regulation of stress fiber assembly|
|cellular response to UV|
|regulation of response to endoplasmic reticulum stress|
|regulation of phospholipid metabolic process|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of tumor necrosis factor production|
|protein phosphatase binding|
|insulin receptor signaling pathway|
|cellular glucose homeostasis|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of protein localization to plasma membrane|
|protein import into nucleus|
|extrinsic apoptotic signaling pathway|
|negative regulation of leukocyte differentiation|
|regulation of nucleocytoplasmic transport|
|B cell differentiation|
|phosphatidylinositol biosynthetic process|
|cellular response to light stimulus|
|regulation of cell-matrix adhesion|
|regulation of protein localization to cell periphery|
|import into nucleus|
|regulation of myeloid leukocyte differentiation|
|regulation of protein localization to nucleus|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of protein localization to membrane|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|regulation of RNA splicing|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|negative regulation of hemopoiesis|
|platelet activation|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|protein import|
|response to UV|
|regulation of tumor necrosis factor production|
|intrinsic apoptotic signaling pathway|
|regulation of tumor necrosis factor superfamily cytokine production|
|B cell activation|
|positive regulation of intracellular protein transport|
|protein localization to nucleus|
|cellular response to insulin stimulus|
|positive regulation of protein kinase B signaling|
|phosphatidylinositol metabolic process|
|cell-cell junction|
|Fc-epsilon receptor signaling pathway|
|cellular response to radiation|
|T cell receptor signaling pathway|
|protein stabilization|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of protein localization to membrane|
|positive regulation of T cell activation|
|lipid modification|
|positive regulation of transmembrane transport|
|glycerophospholipid biosynthetic process|
|positive regulation of intracellular transport|
|regulation of cell-substrate adhesion|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|regulation of myeloid cell differentiation|
|response to insulin|
|regulation of intracellular protein transport|
|lymphocyte differentiation|
|Fc receptor signaling pathway|
|phospholipid biosynthetic process|
|positive regulation of cell-cell adhesion|
|response to endoplasmic reticulum stress|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|nucleocytoplasmic transport|
|nuclear transport|
|cellular response to peptide hormone stimulus|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|apoptotic signaling pathway|
|regulation of protein stability|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|response to light stimulus|
|glycerophospholipid metabolic process|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of T cell activation|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|phagocytosis|
|leukocyte differentiation|
|transcription factor binding|
|regulation of actin cytoskeleton organization|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|positive regulation of lymphocyte activation|
|axonogenesis|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|leukocyte migration|
|lymphocyte activation|
|regulation of actin filament-based process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|axon development|
|positive regulation of cell activation|
|positive regulation of protein transport|
|establishment of protein localization to organelle|
|cell morphogenesis involved in neuron differentiation|
|response to radiation|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|response to peptide|
|wound healing|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|cell projection morphogenesis|
|regulation of body fluid levels|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|organophosphate biosynthetic process|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|response to wounding|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|neuron projection development|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|viral process|
|regulation of protein transport|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|cellular response to DNA damage stimulus|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|intracellular protein transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|immune effector process|
|cell death|
|response to cytokine|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.71|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.76|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.78|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.81|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.83|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.03|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.1|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.14|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.16|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.24|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mapkap1|MAPKAP1]]|0.456|
|[[:human genes:p:pik3cd|PIK3CD]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12219
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3R1 Expression in NALM6 Cells: 8.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>